14638-69-8Relevant articles and documents
Hydroxylamine-Derived Reagent as a Dual Oxidant and Amino Group Donor for the Iron-Catalyzed Preparation of Unprotected Sulfinamides from Thiols
Chatterjee, Sayanti,Makai, Szabolcs,Morandi, Bill
supporting information, p. 758 - 765 (2020/11/30)
An iron catalyzed reaction for the selective transformation of thiols (-SH) to sulfinamides (-SONH2) by a direct transfer of -O and free -NH2 groups has been developed. The reaction operates under mild conditions using a bench stable hydroxylamine derived reagent, exhibits broad functional group tolerance, is scalable and proceeds without the use of any precious metal catalyst or additional oxidant. This novel, practical reaction leads to the formation of two distinct new bonds (S=O and S?N) in a single step to chemoselectively form valuable, unprotected sulfinamide products. Preliminary mechanistic studies implicate the role of the alcoholic solvent as an oxygen atom donor.
Method for synthesizing tert-butyl sulfenamide
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Paragraph 0015; 0018-0026, (2019/08/20)
The invention belongs to the technical field of chemical synthesis, and particularly relates to a method for synthesizing tert-butyl sulfenamide. The invention aims to solve the problems of a long reaction route, a low reaction speed, a large amount of wastewater and application of a highly toxic product chlorine gas in the prior art. The method for preparing tert-butyl sulfinamide comprises the steps: (1) using tert-butyl disulfide as a starting material, and performing oxidative synthesis of tert-butyl sulfoxide tert-butyl ester under the action of a VO(acac)2 catalyst and hydrogen peroxide;and (2) performing bromination on the tert-butyl sulfoxide tert-butyl ester by using bromine in a solvent, and performing ammoniation by using ammonia water so as to obtain tert-butyl sulfenamide. The method has easily available raw materials, simple operation, safety and environmental protection, low cost and high yield, and is a suitable method for preparation of tert-butyl sulfenamide.
A synthetic method of a medicine raw material tert-butylsulfinamide
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Paragraph 0006, (2016/12/01)
The invention relates to a synthetic method of a medicine raw material tert-butylsulfinamide. The method includes subjecting sulfinamide and iso-butane which are raw materials to demethylation at 180-220 DEG C under 2-3 atmospheric pressures to generate the tert-butylsulfinamide. The method is simple, efficient, safe in operation and particularly practical in practical production.
