146684-74-4 Usage
General Description
Z-D-TIC-OH, also known as 5-(3,4-dihydroxybenzoyl)-1,2,3,3a,8,8a-hexahydro-3,3,8,8-tetramethyl-1,3a,4,7-diepoxyazuleno[4,5-b]furan-5-ol, is a synthetic derivative of the natural product podophyllotoxin. It is an antineoplastic agent that inhibits the growth of cancer cells by interfering with their ability to replicate DNA. Z-D-TIC-OH exerts its effects by binding to tubulin, a component of the cytoskeleton that is essential for cell division. This disrupts the formation of the mitotic spindle, ultimately leading to cell death. Z-D-TIC-OH has shown potential as a treatment for various types of cancer, including melanoma and leukemia, and is being studied for its potential use in combination therapies to enhance its efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 146684-74-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,6,8 and 4 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 146684-74:
(8*1)+(7*4)+(6*6)+(5*6)+(4*8)+(3*4)+(2*7)+(1*4)=164
164 % 10 = 4
So 146684-74-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H17NO4/c20-17(21)16-10-14-8-4-5-9-15(14)11-19(16)18(22)23-12-13-6-2-1-3-7-13/h1-9,16H,10-12H2,(H,20,21)/t16-/m1/s1
