1467-21-6Relevant articles and documents
Curtius-like Rearrangement of an Iron-Nitrenoid Complex and Application in Biomimetic Synthesis of Bisindolylmethanes
Li, Dashan,Wu, Ting,Liang, Kangjiang,Xia, Chengfeng
, p. 2228 - 2231 (2016)
A Curtius-like rearrangement of hydroxamates to isocyanates was discovered. This reaction was initiated from an iron(II)-nitrenoid complex, which was generated by the iron(II)-catalyzed cleavage of N-O bonds of functionalized hydroxamates. To demonstrate the efficiency of this new Curtius-like rearrangement in synthetic chemistry, a biomimetic strategy for the one-pot preparation of bisindolylmethanes was developed.
Broad Scope and High-Yield Access to Unsymmetrical Acyclic [11C]Ureas for Biomedical Imaging from [11C]Carbonyl Difluoride
Jakobsson, Jimmy E.,Jana, Susovan,Lu, Shuiyu,Pike, Victor W.,Telu, Sanjay
supporting information, p. 10369 - 10376 (2021/06/07)
Effective methods are needed for labelling acyclic ureas with carbon-11 (t1/2=20.4 min) as potential radiotracers for biomedical imaging with positron emission tomography (PET). Herein, we describe the rapid and high-yield syntheses of unsymmet
Stabilization of the hindered urea bond through de-tert-butylation
Yang, Yingfeng,Ying, Hanze,Jia, Yunchao,Chen, Yingying,Cheng, Jianjun
supporting information, p. 3812 - 3815 (2021/04/21)
We report the discovery of an acid-assisted de-tert-butylation reaction that can instantly “turn off” the dynamicity of hindered urea bonds (HUBs) and thus broaden their applications. The reaction is demonstrated to be widely applicable to different hindered urea substrates, leading to improved chemical stabilities and mechanical properties of HUB-containing materials.
