14690-01-8Relevant articles and documents
Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines
Hussein, Waleed M.,Liu, Tzu-Yu,Maruthayanar, Pirashanthini,Mukaida, Saori,Moyle, Peter M.,Wells, James W.,Toth, Istvan,Skwarczynski, Mariusz
, p. 2308 - 2321 (2016)
Conjugation of multiple peptides by their N-termini is a promising technique to produce branched multiantigenic vaccines. We established a double conjugation strategy that combines a mercapto-acryloyl Michael addition and a copper-catalysed alkyne-azide 1,3-dipolar cycloaddition (CuAAC) reaction to synthesise self-adjuvanting branched multiantigenic vaccine candidates. These vaccine candidates aim to treat cervical cancer and include two HPV-16 derived epitopes and a novel self-adjuvanting moiety. This is the first report of mercapto-acryloyl conjugation applied to the hetero conjugation of two unprotected peptides by their N-termini followed by a CuAAC reaction to conjugate a novel synthetic lipoalkyne self-adjuvanting moiety. In vivo experiments showed that the most promising vaccine candidate completely eradicated tumours in 46% of the mice (6 out of 13 mice).
Clickosomes - Using triazole-linked phospholipid connectors to fuse vesicles
Loosli, Frederic,Doval, David Alonso,Grassi, David,Zaffalon, Pierre-Leonard,Favarger, France,Zumbuehl, Andreas
supporting information; experimental part, p. 1604 - 1606 (2012/03/11)
Two complementary artificial diether phospholipids were synthesized that can undergo a Cu(i)-catalyzed Huisgen-Sharpless click reaction. The resulting lipid can bridge the membranes of large unilamellar vesicles and cause their aggregation and ultimately their fusion.
Complex hydrophobe-containing oligomers
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, (2008/06/13)
This invention relates to polymers, especially emulsion polymers, and their use for the thickening of a variety of aqueous systems, to methods of thickening utilizing the polymers, to enhancement of such thickening by the addition of surfactants, solvents or non-solvents, and to other aspects including coating compositions and other aqueous systems thickened with the polymers. This invention also relates to new complex hydrophobe-containing oligomers and their use in producing the polymers of this invention.
