146986-50-7 Usage
Uses
Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor.
Definition
ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti
ity against Rho-associated protein kinase (ROCK) enzyme.
Biological Activity
Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation.
references
[1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83.
Check Digit Verification of cas no
The CAS Registry Mumber 146986-50-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,9,8 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 146986-50:
(8*1)+(7*4)+(6*6)+(5*9)+(4*8)+(3*6)+(2*5)+(1*0)=177
177 % 10 = 7
So 146986-50-7 is a valid CAS Registry Number.