147227-26-7Relevant articles and documents
A convenient route to (E)-α,β-unsaturated methyl ketones
Bellassoued,Aatar,Bouzid,Damak
experimental part, p. 1886 - 1895 (2010/11/18)
Aldehydes are converted into (E)-α,β-unsaturated methyl ketones in good yield and with a high E stereoselectivity using α,α- bis(trimethylsilyl) N-tert-butyl acetimine 3. The reaction was mediated by a catalytic amount of tetrabutylammonium fluoride (TBAF) under mild conditions. The disilylated reagent 3 is easily generated from N-tert-butylacetimine, lithium diisopropylamide (LDA), and chlorotrimethylsilane. The mechanism of the reaction is discussed. Copyright