149968-11-6Relevant articles and documents
Preparation method of montelukast sodium drug intermediate
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Paragraph 0004; 0023-0037, (2021/05/01)
The invention relates to a preparation method of a montelukast sodium drug intermediate, wherein the method comprises the following steps: uniformly mixing a compound II, a compound III, alkali and a solvent, and carrying out chemical reaction at the temperature of 80-150 DEG C in the presence of a catalyst to prepare an intermediate compound I, wherein the catalyst is CuCl, CuBr or CuI; and specific synthetic route is described in the specification. According to the preparation method, the catalyst is low in cost, high in catalytic activity, mild in reaction condition and environmentally friendly, the yield reaches 90% or above, the purity reaches 99% or above, repeated cyclic utilization can be achieved after simple filtration and separation, and industrial production of the montelukast sodium drug intermediate is easier.
For the synthesis of montelukast intermediate compound and its preparation method
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, (2017/08/25)
The invention relates to a medicine intermediate and a preparation method thereof, and especially relates to an intermediate compound for synthesizing montelukast, and a preparation method thereof. The intermediate compound is represented by formula (2); and in the formula (2), R'' is a C1-4 alkyl group, and X is halogen.
AN IMPROVED PROCESS FOR THE PREPARATION OF MONTELUKAST SODIUM AND ITS INTERMEDIATES
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Page/Page column 5; 6; 10; 11, (2010/06/20)
The present invention relates to a process for the preparation of montelukast sodium (formula 1) and formula 4. The invention concerns the coupling of thiol derivative, Methyl 1 - (mercaptomethyl)cyclopropane acetate with mesylate of formula 4 compound using alkyl substituted ammonium hydroxide base, alkali amides and purification of Montelukast acid by crystallization in suitable organic solvents. The invention further concerns to provide an improved process of montelukast intermediates having good yield and quality
