150349-36-3Relevant articles and documents
Bis(acridinylthiourea)platinum(II) complexes: Synthesis, DNA affinity, and biological activity in glioblastoma cells
Augustus, Todd M.,Anderson, Joel,Hess, Suzanne M.,Bierbach, Ulrich
, p. 855 - 858 (2003)
The preparation of two novel bis(acridine)platinum(II) complexes is reported. The 4+ charged conjugates associate strongly with double-stranded native DNA (Ki>106), possibly through bisintercalation. A cell viability assay was used to demonstrate that both compounds are capable of mediating cytotoxicity at micromolar concentrations in SNB19 brain tumor cells.
In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells
Byun, Joon Seok,Sohn, Joo Mi,Leem, Dong Gyu,Park, Byeongyeon,Nam, Ji Hye,Shin, Dong Hyun,Shin, Ji Sun,Kim, Hyoung Ja,Lee, Kyung-Tae,Lee, Jae Yeol
, p. 1073 - 1079 (2016/07/26)
As a result of our continuous research, new 3,4-dihydroquinazoline derivative containing ureido group, KCP10043F was synthesized and evaluated for T-type Ca2+channel (Cav3.1) blockade, cytotoxicity, and cell cycle arrest against huma
COMPOUNDS AND METHODS
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Page/Page column 40, (2013/03/26)
Disclosed are compounds having formula I, wherein X1, X2, X3, R1, R2, R3, R4, R5, Y, A, Z, L, m and n are as defined herein, and methods of making and using the same.