150566-71-5Relevant articles and documents
Preparation method of levamlodipine benzenesulfonate (by machine translation)
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Paragraph 0095-0097, (2020/07/24)
The invention belongs to the technical field of drug synthesis and provides a production method of levamlodipine benzenesulfonate, which comprises the following steps: (R, S)-amlodipine is reacted with a resolving agent. The method is simple and convenient to operate, does not need special equipment, and has a better industrial application prospect. (by machine translation)
A novel chiral resolving reagent, bis((s)-mandelic acid)-3-nitrophthalate, for amlodipine racemate resolution: Scalable synthesis and resolution process
Lee, Hong Woo,Shin, Sung Jae,Yu, Hosung,Kang, Sung Kwon,Yoo, Choong Leol
experimental part, p. 1382 - 1386 (2010/04/22)
A novel bis((S)-mandelic acid)-3-nitrophthalate (1), a chiral resolving reagent for the separation of (S)-(-)-isomers of amlodipine from the racemate thereof, is designed and synthesized. A simple three-step pilot-scale preparation of 1, along with the optimization of a resolution process on the racemate amlodipine, is reported.
PROCESS FOR PRODUCING ENANTIOMER OF AMLODIPINE IN HIGH OPTICAL PURITY
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Page/Page column 17-18, (2010/11/08)
The present invention relates to a process for preparation of optically pure (S)-amlodipine-L-hemitartrate DMF solvate comprising the steps of treating (R,S) amlodipine base with L-tartaric acid in the presence of dimethyl formamide and a co-solvent. The invention also relates to a process for converting (R) or(S)-amlopidine-L-hemitartrate DMF solvate into their besylates without isolating free chiral amlopidine base after solution.
