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151804-77-2

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151804-77-2 Usage

Biological Activity

amylin is a 37-amino acid peptide co-secreted with insulin from pancreatic β-ells. the plasma concentration of amyline increases with nutrient stimuli. ac187 is a potent amylin antagonist

in vitro

ac187 potently competes for rat amylin binding at high affinity sites such as rat nucleus accumbens membranes which have been useful in developing a number of selective ligands, including ac187. the kd for amylin at this site is 28 pm, and the ki for ac187 is 79 pm. ac187 is relatively selective in competing for amylin binding, displacing amylin from nucleus accumbens membranes with over 400-fold greater potency [1].

in vivo

ac187 was able to inhibit metabolic responses to exogenous amylin in the intact animal. an infusion of ac187 that was itself without effect on lactate levels in anesthetized rats, inhibited by more than 90% the lactate increment evoked by infusions of rat amylin. other experiments have shown that ac187-induced amylin blockade action is surmountable by higher doses of amylin, indicative of a competitive antagonism [1].

references

[1] young aa, gedulin b, gaeta ls, prickett ks, beaumont k, larson e, rink tj. selective amylin antagonist suppresses rise in plasma lactate after intravenous glucose in the rat. evidence for a metabolic role of endogenous amylin. febs lett. 1994 may 2;343(3):237-41.

Check Digit Verification of cas no

The CAS Registry Mumber 151804-77-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,8,0 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 151804-77:
(8*1)+(7*5)+(6*1)+(5*8)+(4*0)+(3*4)+(2*7)+(1*7)=122
122 % 10 = 2
So 151804-77-2 is a valid CAS Registry Number.

151804-77-2 Well-known Company Product Price

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  • Sigma

  • (SML1418)  AC187 trifluoroacetate salt  ≥95% (HPLC)

  • 151804-77-2

  • SML1418-1MG

  • 3,447.99CNY

  • Detail

151804-77-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name AC 187

1.2 Other means of identification

Product number -
Other names ACETYL-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:151804-77-2 SDS

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