151985-13-6Relevant articles and documents
The Use of Two Linked Scanning Modes in Alternation to Analyse Metastable Peaks
Lacey, Michael J.,Macdonald, Colin G.
, p. 134 - 137 (1980)
Analyses of masses relative kinetic energies for metastable peaks may be achieved by the use in alternation of two types of linked scans of the electric sector voltage and magnetic field.The method is demonstrated by an appraisal of hydrogen exchange in molecular ions of 2-methyl-2H3>-benzoic acid.
Copper-Catalyzed Modular Access to N-Fused Polycyclic Indoles and 5-Aroyl-pyrrol-2-ones via Intramolecular N—H/C—H Annulation with Alkynes: Scope and Mechanism Probes
Liu, Yan-Hua,Song, Hong,Zhang, Chi,Liu, Yue-Jin,Shi, Bing-Feng
supporting information, p. 1545 - 1552 (2020/09/09)
Copper-catalyzed intramolecular N—H/C—H annulation with alkynes has been developed. A variety of densely functionalized heterocycles, such as pyrrolo[1,2-a]indoles, indolo[1,2-c]quinazolin-2-ones, oxazolo[3,4-a]indoles, and imidazo[1,5-a]indoles, were synthesized in an atom- and step-economical manner, owing to the high modularized feature of aniline moiety, the linker moiety, as well as the alkyne moiety. By simply changing the oxidant from di-tert-butyl peroxide (DTBP) to 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), the reaction could readily be transformed to the aminooxygenation pathway, which grabs one oxygen atom from the TEMPO to generate 5-aroyl-pyrrol-2-ones. Mechanistic experiments indicate that vinyl radical is involved in this reaction and an amidyl-radical-initiated radical cascade might be responsible for this transformation.
Palladium catalyzed acetoxylation of benzylic C-H bonds using a bidentate picolinamide directing group
Cheng, Tao,Yin, Weiyu,Zhang, Yi,Zhang, Yingnan,Huang, Yong
supporting information, p. 1405 - 1411 (2014/03/21)
A general palladium catalyzed acetoxylation of benzylic C-H bonds has been developed. Picolinamides serve as an excellent directing group for the C-H activation of benzylic methyls. A wide range of 2-amino benzyl alcohol analogues were synthesized in good yields. The products demonstrated broad synthetic utilities toward various benzo-fused heterocycles. Mechanistic studies revealed the key rate-limiting C-H insertion step, which could be affected by the substitution pattern of the parent arene.