152657-84-6

• 

• Basic information

  1. Product Name: NALFURAFINE
  2. Synonyms: NALFURAFINE;Nalfuranfine;(E)-N-[(5alpha,6beta)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-2-propenamide;Nalfuranfine impurity
  3. CAS NO:152657-84-6
  4. Molecular Formula: C28H32N2O5
  5. Molecular Weight: 476.57
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 152657-84-6.mol
  9. Article Data: 4

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 700.7°Cat760mmHg
  3. Flash Point: 377.6°C
  4. Appearance: /
  5. Density: 1.41g/cm³
  6. Vapor Pressure: 1.3E-20mmHg at 25°C
  7. Refractive Index: 1.696
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. PKA: 9.37±0.60(Predicted)
  11. CAS DataBase Reference: NALFURAFINE(CAS DataBase Reference)
  12. NIST Chemistry Reference: NALFURAFINE(152657-84-6)
  13. EPA Substance Registry System: NALFURAFINE(152657-84-6)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 152657-84-6(Hazardous Substances Data)

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• SDS
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• Downstream Products
• Article

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• 2-Propenamide, N-[(5a,6b)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-,(2E)-/ LIDE PHARMA- Factory supply / Best price

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• 2-Propenamide, N-[(5a,6b)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-,(2E)- CAS No.152657-84-6

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152657-84-6 Usage

Uses

Treatment of uremic pruritus in hemodialysis patients.

Check Digit Verification of cas no

The CAS Registry Mumber 152657-84-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,6,5 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 152657-84:
(8*1)+(7*5)+(6*2)+(5*6)+(4*5)+(3*7)+(2*8)+(1*4)=146
146 % 10 = 6
So 152657-84-6 is a valid CAS Registry Number.

InChI:InChI=1/C28H32N2O5/c1-29(23(32)7-4-18-9-13-34-16-18)20-8-10-28(33)22-14-19-5-6-21(31)25-24(19)27(28,26(20)35-25)11-12-30(22)15-17-2-3-17/h4-7,9,13,16-17,20,22,26,31,33H,2-3,8,10-12,14-15H2,1H3/b7-4+/t20-,22-,26+,27+,28-/m1/s1

152657-84-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name	(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide

1.2 Other means of identification

Product number	-
Other names	Nalfurafine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:152657-84-6 SDS

152657-84-6Upstream product

• 81311-96-8 trans-3-(furan-3-yl)acryloyl chloride 
• 102869-99-8 6β-N-methylnaltrexamine 
• 39244-10-5 (E)-3-furan-3-yl-acrylic acid 
• 16590-41-3 Naltrexone 
• 39244-10-5 3-(furan-3-yl)prop-2-enoic acid 

152657-84-6Downstream Products

• 152658-17-8 nalfurafine hydrochloride 

152657-84-6Relevant articles and documents

Discovery of a structurally novel opioid κ-agonist derived from 4,5- epoxymorphinan

Nagase, Hiroshi,Hayakawa, Jun,Kawamura, Kuniaki,Kawai, Kouji,Takezawa, Yuko,Matsuura, Hirotoshi,Tajima, Chiko,Endo, Takashi

, p. 366 - 369 (1998)

A new type of κ-agonist, 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α- epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride (1, TRK-820), was discovered by a new working hypothesis. The 'message-address concept' for opioid antagonists and the 'accessory site' for general antagonists were applied to design TRK-820. A unique structural feature of TRK-820, which is different from other prototypical κ-opioid receptor agonists, is the existence of the 4,5-epoxymorphinan structure with a tyrosine-glysine moiety for endogenous opioid peptides such as dynorphins. TRK-820 exhibited high potency and high κ-selectivity in guinea pig ileum (GPI) and mouse vas deferens (MVD) preparations. In the mouse acetic-acid- induced writhing model and mouse tail flick model of antinociception, TRK- 820 was 85-140 times more potent than morphine and 85-350 times more potent than U-50488H. This structurally novel κ-agonist showed neither aversion nor preference in the Conditioned Place Preference test, in spite of the fact that prototypes of κ-agonists (U-50488H derivatives) demonstrated aversion.

Crystals of morphinan derivative, manufacturing method thereof, and pharmaceutical composition using the same

-

, (2014/09/03)

The present invention relates to a X-form crystal of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride and the manufacturing method thereof, wherein the X-form crystal of the compound has char

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