153587-01-0 Usage
Uses
NS 1619 is a large conductance calcium-activated potassium channels (BKCa) activator and has been shown to induce precondition in the heart.
Definition
ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It i
an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Biochem/physiol Actions
NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.
Check Digit Verification of cas no
The CAS Registry Mumber 153587-01-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,5,8 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 153587-01:
(8*1)+(7*5)+(6*3)+(5*5)+(4*8)+(3*7)+(2*0)+(1*1)=140
140 % 10 = 0
So 153587-01-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
153587-01-0Relevant articles and documents
Benzimidazole derivatives, their preparation and pharmaceutical use
-
, (2008/06/13)
A compound having the formula STR1 wherein X is O, SR 4, R 5, R 6 and R 7 independently of each other are hydrogen, halogen, or CF 3 ;R'' is hydrogen or NO 2 ; andfurther a method of treating a disorder or disease of a living animal body, including a huma
