154-97-2Relevant articles and documents
A simple process for the preparation of pralidoxime chloride
Unnisa, Lateef,Sumakanth,Rao, B. Leelamaheswara,Divi, Murali Krishnaprasad,Rao, Mysore Aswathanarayana
, p. 431 - 435 (2014/05/06)
Pralidoxime chloride (2-PAM chloride) is an important drug included in National List of Essential Medicines-2003 for treating pesticide poisoning. However, the current methods for its preparation use hazardous methyl halides such as methyl chloride or methyl iodide. In the present work, reaction of pyridine-2- aldoxime with methyl methanesulfonate in acetonitrile gave 2-PAM mesylate in high yields (90%). Use of methyl tosylate in toluene resulted in 2-PAM tosylate (90% yield). Both 2-PAM mesylate and 2-PAM tosylate on treatment with dry hydrogen chloride in isopropanol, resulted in 2-PAM chloride in high yields (90%) and purity (>99%).