15404-76-9Relevant articles and documents
Yates,Bhat
, p. 3770 (1968)
Acetyl- and O-alkyl- derivatives of β-mangostin from Garcinia mangostana and their anti-inflammatory activities
Karunakaran, Thiruventhan,Ee, Gwendoline Cheng Lian,Ismail, Intan Safinar,Mohd Nor, Siti Mariam,Zamakshshari, Nor Hisam
, p. 1 - 5 (2017)
Pure β-mangostin (1) was isolated from the stem bark of Garcinia mangostana L. One monoacetate (2) and five O-alkylated β-mangostin derivatives (3–7) were synthesised from β-mangostin. The structures of these compounds were elucidated and determined using spectroscopic techniques such as 1D NMR and MS. The cytotoxicities and anti-inflammatory activities of these five compounds against RAW cell 264.7 were tested. The structural-activity relationship studies indicated that β-mangostin showed a significant activity against the LPS-induced RAW cell 264.7, while the acetyl- as well as the O-alkyl- β-mangostin derivatives did not give good activity. Naturally occurring β-mangostin demonstrated comparatively better anti-inflammatory activity than its synthetic counterparts.
Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents
Chi, Xiao-Qian,Zi, Cheng-Ting,Li, Hong-Mei,Yang, Liu,Lv, Yong-Feng,Li, Jin-Yu,Hou, Bo,Ren, Fu-Cai,Hu, Jiang-Miao,Zhou, Jun
, p. 41377 - 41388 (2019/01/03)
In order to better understand the structure-activity relationship of mangostin, a series of xanthone derivatives based on α-mangostin were designed and synthesized. All the compounds were evaluated for their cytotoxicity against a panel of five human canc