15687-18-0 Usage
Originator
Tredum,Heacutepatrol
Uses
2-(4-chlorophenyl)-4-methylpentane-2,4-diol is a pharmaceutical drug with analgesic, antipyretic, and antihistaminic properties and can be used for preventative or early treatment of inflammatory syndromes.
Manufacturing Process
2-(p-Chlorophenyl)-4-methylpentane-2,4-diol (M.P. 76.5°C) was synthesized
and condensation of 2-(p-chlorophenyl)-3-hydroxybytiric acid ethyl ester with
CH3 MgI in ether.
Therapeutic Function
Antidepressant, Tranquilizer
Check Digit Verification of cas no
The CAS Registry Mumber 15687-18-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,6,8 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 15687-18:
(7*1)+(6*5)+(5*6)+(4*8)+(3*7)+(2*1)+(1*8)=130
130 % 10 = 0
So 15687-18-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H17ClO2/c1-11(2,14)8-12(3,15)9-4-6-10(13)7-5-9/h4-7,14-15H,8H2,1-3H3
15687-18-0Relevant articles and documents
Triflimide: An Overlooked High-Performance Catalyst of the Mukaiyama Aldol Reaction of Silyl Ketene Acetals with Ketones
Bae, Han Yong,List, Benjamin
, p. 13767 - 13772 (2018/09/12)
The Mukaiyama aldol reaction is a widely applied carbon–carbon bond forming reaction. However, despite numerous well-established methods using aldehydes as acceptors, only few examples exist with ketones. Here we report a highly practical catalytic approach to this transformation, namely, the triflimide catalyzed Mukaiyama aldol reaction of silyl ketene acetals with ketones. This method exhibits a broad substrate scope, is very rapid, tolerates functionalized substrates, and requires only parts-per-million catalyst loadings with preparative scale reactions up to hundreds of grams in excellent purity (>99 %).
