157327-41-8

• 

• Basic information

  1. Product Name: 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine
  2. Synonyms: 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine;3-[(Dimethylamino)methylene]piperidin-4-one, N1-BOC protected;tert-butyl 3-[(diMethylaMino)Methylidene]-4-oxopiperidine-1-carboxylate;3-[(Dimethylamino)methylene]-4-oxopiperidine-1-carboxylic acid tert-butyl ester;-4-oxopiperidine-1-carboxylate;tert-Butyl 3-((dimethylamino)
  3. CAS NO:157327-41-8
  4. Molecular Formula: C₁₃H₂₂N₂O₃
  5. Molecular Weight: 254.328
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 157327-41-8.mol
  9. Article Data: 27

• Chemical Properties

  1. Melting Point: 85～87℃
  2. Boiling Point: 357.9°C at 760 mmHg
  3. Flash Point: 170.2°C
  4. Appearance: /
  5. Density: 1.144g/cm³
  6. Vapor Pressure: 2.65E-05mmHg at 25°C
  7. Refractive Index: 1.55
  8. Storage Temp.: 2-8°C
  9. Solubility: N/A
  10. PKA: 5.07±0.20(Predicted)
  11. CAS DataBase Reference: 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine(CAS DataBase Reference)
  12. NIST Chemistry Reference: 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine(157327-41-8)
  13. EPA Substance Registry System: 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine(157327-41-8)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 157327-41-8(Hazardous Substances Data)

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157327-41-8 Suppliers

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• 1-BOC-3-((DIMETHYLAMINO)METHYLENE)-4-OXOPIPERIDINE

  Cas No: 157327-41-8

• USD $ 3.0-3.0 / Kilogram

• 1 Kilogram

• 1-100 Metric Ton/Month

• Dayang Chem (Hangzhou) Co.,Ltd.
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• 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine

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• Hangzhou J&H Chemical Co., Ltd.
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• 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine

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• 1 Kilogram

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• Zibo Dorne chemical technology co. LTD
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• 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine

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• Hangzhou Huarong Pharm Co., Ltd.
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• 1-Boc-3-[(DiMethylaMino)Methylene]-4-oxopiperidine

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• Henan Allgreen Chemical Co.,Ltd
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• 3-[(Dimethylamino)methylene]piperidin-4-one, N1-BOC protected

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• 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine

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• ZHEJIANG JIUZHOU CHEM CO.,LTD
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• tert-Butyl 3-((dimethylamino)methylene)-4-oxopiperidine-1-carboxylate

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• Bide Pharmatech Ltd
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• 3-(dimethylaminomethylidene)-4-oxo-1-piperidinecarboxylic acid tert-butyl ester

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• Amadis Chemical Co., Ltd.
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• 1-BOC-3-((DIMETHYLAMINO)METHYLENE)-4-OXOPIPERIDINE CAS NO.157327-41-8

  Cas No: 157327-41-8

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157327-41-8 Usage

General Description

1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine, also known as N-Boc-DMA-Pip, is a chemical compound that is used in organic synthesis as a reagent or intermediate. It is a piperidine derivative with a Boc (tert-butoxycarbonyl) protecting group on the nitrogen atom and a dimethylamino functional group on the third carbon. 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine has applications in medicinal chemistry, particularly in the development of pharmaceuticals and bioactive molecules. It is also used in the synthesis of complex organic molecules and as a building block for various chemical reactions. Additionally, N-Boc-DMA-Pip has been studied for its potential as a chiral auxiliary in asymmetric synthesis and as a catalyst in organic transformations.

Check Digit Verification of cas no

The CAS Registry Mumber 157327-41-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,3,2 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 157327-41:
(8*1)+(7*5)+(6*7)+(5*3)+(4*2)+(3*7)+(2*4)+(1*1)=138
138 % 10 = 8
So 157327-41-8 is a valid CAS Registry Number.

InChI:InChI=1/C13H22N2O3/c1-13(2,3)18-12(17)15-7-6-11(16)10(9-15)8-14(4)5/h8H,6-7,9H2,1-5H3/b10-8-

157327-41-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name	1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine

1.2 Other means of identification

Product number	-
Other names	3-Dimethylaminomethyl-but-3-en-2-on

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:157327-41-8 SDS

157327-41-8Upstream product

• 127-19-5 N,N-dimethyl acetamide 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

157327-41-8Downstream Products

• 1454656-61-1 6-(2-methanesulfinyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (4-isopropyl-phenyl)-amide 
• 1454656-47-3 6-{2-amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl}-N-[4-(isopropyl)phenyl]pyridine-2-carboxamide 
• 1454656-60-0 N-(4-isopropylphenyl)-6-[2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]pyridine-2-carboxamide 
• 1454657-51-2 methyl-4-methyl-3-[2-(methylsulfanyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl]benzoate 
• 1454656-93-9 3-[2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]-N-[3-(trifluoromethyl)phenyl]benzamide 
• 1454656-96-2 N-(3-isopropylphenyl)-4-methyl-3-[2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]benzamide 
• 1454657-06-7 3-(7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-[3-(trifluoromethyl)phenyl]benzamide 
• 869198-95-8 2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-carboxylic acid tert-butyl ester 
• 1613148-19-8 3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)pyridin-2-amine 
• 1567965-09-6 tert-butyl 2-(cyclopropylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate 
• 124458-31-7 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine 
• 259809-78-4 t-butyl-2-(methylthio)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylate 

157327-41-8Relevant articles and documents

Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold

Deng, Yongqi,Doty, Amy,Ferguson, Heidi,Fradera, Xavier,Han, Yongxin,Jonathan Bennett, David,Knemeyer, Ian,Lesburg, Charles A.,Li, Derun,Liu, Kun,Martinot, Theo,Otte, Karin,Richard Miller, J.,Sciammetta, Nunzio,Sloman, David,Vincent, Stella,Yu, Wensheng

, (2021/08/27)

A series of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold were identified with good cellular and human whole blood activity against IDO1. These inhibitors contain multiple chiral centers and all diastereomers were separated. The absolute stereochemistry of each isomers were not determined. Compounds 15 and 27 stood out as leads due to their good cellular as well as human whole blood IDO1 inhibition activity, low unbound clearance, and reasonable mean residence time in rat cassette PK studies.

2-(2-pyridine)-6-(2-chloro-3-trifluoromethylbenzoyl)-5,7,8-trihydropyrido [4,3-d] pyrimidine and preparation method thereof

-

Paragraph 0025; 0030, (2018/03/01)

The invention discloses 2-(2-pyridine)-6-(2-chloro-3-trifluoromethylbenzoyl)-5,7,8-trihydropyrido [4,3-d] pyrimidine and a preparation method thereof. The structure of the 2-(2-pyridine)-6-(2-chloro-3-trifluoromethylbenzoyl)-5,7,8-trihydropyrido [4,3-d] pyrimidine is as shown in the formula (I), and the 2-(2-pyridine)-6-(2-chloro-3-trifluoromethylbenzoyl)-5,7,8-trihydropyrido [4,3-d] pyrimidine belongs to a novel pyridopyrimidine compound and a novel anticancer drug is provided for human beings. The research field of pyridopyrimidine compounds is widened, the reaction total yield of the compound is high, the process is simple, and the method is suitable for industrial production.

FUSED HETEROCYCLIC COMPOUNDS AS S1P MODULATORS

-

Page/Page column 70; 71, (2017/03/28)

The invention relates to heterocyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.

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