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158985-25-2

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158985-25-2 Usage

General Description

1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE is a chemical compound that belongs to the piperazine class of compounds. It contains a BOC (tert-butoxycarbonyl) protecting group attached to the nitrogen atom of the piperazine ring and a 4-hydroxyphenyl substituent. 1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE is commonly used in the synthesis of pharmaceuticals and agrochemical products, as well as in research and development. Its structure and properties make it useful for the modification and design of new compounds with potential therapeutic applications. Additionally, the 4-hydroxyphenyl substituent makes it a valuable component for the development of bioconjugates and targeted drug delivery systems.

Check Digit Verification of cas no

The CAS Registry Mumber 158985-25-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,9,8 and 5 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 158985-25:
(8*1)+(7*5)+(6*8)+(5*9)+(4*8)+(3*5)+(2*2)+(1*5)=192
192 % 10 = 2
So 158985-25-2 is a valid CAS Registry Number.

158985-25-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate

1.2 Other means of identification

Product number -
Other names 1-(4-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:158985-25-2 SDS

158985-25-2Relevant articles and documents

Affinity-Based Selectivity Profiling of an In-Class Selective Competitive Inhibitor of Acyl Protein Thioesterase 2

Won, Sang Joon,Eschweiler, Joseph D.,Majmudar, Jaimeen D.,Chong, Fei San,Hwang, Sin Ye,Ruotolo, Brandon T.,Martin, Brent R.

, p. 215 - 220 (2017)

Activity-based protein profiling (ABPP) has revolutionized the discovery and optimization of active-site ligands across distinct enzyme families, providing a robust platform for in-class selectivity profiling. Nonetheless, this approach is less straightfo

ADENOSINE A2A RECEPTOR ANTAGONISTS AND USES THEREOF

-

Paragraph 00372, (2021/02/12)

Disclosed herein are compounds, compositions, and methods for modulating the A2A2A adenosine receptor with the compounds and compositions disclosed herein. Also described are methods of treating diseases or disorders that are mediated by the A

Truncated Itraconazole Analogues Exhibiting Potent Anti-Hedgehog Activity and Improved Drug-like Properties

Wen, Jiachen,Chennamadhavuni, Divya,Morel, Shana R.,Hadden, M. Kyle

, p. 1290 - 1295 (2019/09/30)

We conducted a structure-activity relationship study to explore simplified analogues of the itraconazole (ITZ) scaffold for their ability to inhibit the hedgehog (Hh) signaling pathway. These analogues were based on exploring the effects of chemical modifications to the linker and triazolone/side chain region of ITZ. Analogue 11 was identified as the most potent compound in our first generation, with an IC50 value of 81 nM in a murine Hh-dependent basal cell carcinoma. Metabolic identification studies led us to identify truncated piperazine (26) as the major metabolite in human liver microsomes (HLMs) and an improved Hh pathway inhibitor (IC50 = 22 nM). This work verifies that continued truncation of the ITZ scaffold is a practical method to maintain potent anti-Hh activity while also reducing the molecular weight for the ITZ scaffold and achieving improved pharmacokinetic properties.

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