15986-92-2Relevant articles and documents
Formation of tricyclic heterocycles from the condensation reaction of 1,2-diamines with 1,2-diketones
Yamaguchi, Tadatoshi,Eto, Masashi,Watanabe, Kenji,Kashige, Nobuhiro,Harano, Kazunobu
, p. 1977 - 1979 (1996)
Condensation of 1,2-diamines with 1,2-diketones yielded unexpected tricyclic heterocycles. The structures were determined by single-crystal X- ray analysis.
New compounds derived from dihydropyrazines having DNA strand-breakage activity
Yamaguchi, Tadatoshi,Eto, Masashi,Harano, Kazunobu,Kashige, Nobuhiro,Watanabe, Kenji,Ito, Shigeru
, p. 675 - 686 (1999)
Dihydropyrazine derivatives such as 2,3-dihydro-5,6-dimethylpyrazine (1), 2,3-dihydro-2,5,6-trimethylpyrazine (2) and 2,3-dihydro-2,2,5,6- teramethylpyrazine (3) were found to be transformed into (2R*, 3S*, 5R*)- 1,2 ethylene-imino-1,7,10-triaza-2,3,6-trimethyl-3-hydroxy-spiro [4,5] decan- 6-ene (4), the stereoisomeric mixtures of 2,4aR*,7,9aS* - tetramethylcyclohexano [1,2-e: 4,5-e']-dipiperazin-6-ene (5) and (4aR*, 9aS*)-2,2,4a,7,7,9a-hexamethylcyclohexano [1,2-e: 4,5-e']-dipiperazin-6-ene (6), respectively. These dimerized compounds (4, 5 and 6), whose structures were determined by X-ray and nmr spectral analyses, showed almost the same DNA strand-breakage activity as their parent dihydropyrazines. The dimerization pathway is discussed on the basis of the PM3 calculation data.
A reusable zirconium(IV) Schiff base complex catalyzes highly efficient synthesis of quinoxalines under mild conditions
Jafarpour, Maasoumeh,Rezaeifard, Abdolreza,Haddad, Reza,Gazkar, Somayeh
, p. 31 - 36 (2013/08/24)
A zirconium(IV) complex of a bidentate Schiff base (ZrL2Cl 2) has been synthesized by the reaction of (z)-N-benzylidene-2- hydroxypropane-1-amine (HL) and ZrCl4. Spectroscopic data and elemental analyses are consistent with a monomeric complex with a ligand:Zr ratio of 2:1. The catalytic activity of ZrL2Cl2 has been investigated for the efficient synthesis of a wide variety of quinoxaline derivatives under mild conditions. The employment of ethanol as an environmentally benign solvent in this high yield method, along with high turnover numbers and reusability of the catalyst providing ready scalability, makes it appropriate for practical applications.
Phenyl-substituted dihydropyrazines with DNA strand-breakage activity
Ito, Shigeru,Takechi, Shinji,Nakahara, Kazuhide,Kashige, Nobuhiro,Yamaguchi, Tadatoshi
scheme or table, p. 825 - 828 (2010/09/07)
Monophenyl-substituted dihydropyrazines (Ph-DHP-1 to 4) of 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP-1), which have the inductive effects of apoptosis and mutagenesis, were synthesized and their biological effect was investigated in terms of DNA strand-breakage. Differences between the phenyl- and methyl-substituted dihydropyrazines were examined.
