159878-02-1Relevant articles and documents
Merging lithium carbenoid homologation and enzymatic reduction: A combinative approach to the HIV-protease inhibitor Nelfinavir
Castoldi, Laura,Ielo, Laura,Hoyos, Pilar,Hernáiz, María J.,De Luca, Laura,Alcántara, Andrés R.,Holzer, Wolfgang,Pace, Vittorio
, p. 2211 - 2217 (2018/03/28)
An effective stereocontrolled synthesis of the HIV protease inhibitor Nelfinavir is reported. Two transformations were identified crucial for achieving success: the formation of a densely functionalized α-chloroketone via the homologation of a Weinreb ami
Development of a continuous process for the industrial generation of diazomethane
Proctor, Lee D.,Warr, Antony J.
, p. 884 - 892 (2013/09/06)
The development of a safe process for the industrial generation of diazomethane is described. Diazomethane is produced and consumed in a continuous process capable of generating between 50 and 60 tonnes per year whilst the maximum inventory is maintained
Process for reducing α-amino ketones
-
, (2008/06/13)
The present invention has its objects to provide a method for reducing α-aminoketone derivatives under mild conditions with high stereoselectivity. This invention is a method for reducing α-aminoketone which comprises reacting an a-aminoketone derivative of general formula (1) with a compound prepared from an organoaluminum compound of general formula (4), a sulfonic acid derivative of general formula (5), and an alcohol compound of general formula (6) to give an α-aminoalcohol derivative of general formula (7)