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16078-30-1

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16078-30-1 Usage

Uses

Different sources of media describe the Uses of 16078-30-1 differently. You can refer to the following data:
1. ? ;Reactant for preparation of triazolothiadiazepine dioxide derivatives1? ;Reactant for preparation of halo-substituted aromatic amides2? ;Reactant for preparation of [[(phenyl)piperazinyl]alkyl]indolyl]ethanone and [[[(phenoxyethyl)piperazinyl]alkyl]indolyl]ethanone derivatives as α1-adrenoreceptor antagonists3? ;Reactant for synthesis of naphthalenedione derivatives as antimycobacterial agents4? ;Reactant for regioselective ortho Suzuki-Miyaura coupling reaction5
2. 1-(2,3-Dihydroindol-1-yl)ethanone is an intermediate used for preparation of triazolothiadiazepine dioxide derivatives, halo-substituted aromatic amides and [[(phenyl)piperazinyl]alkyl]indolyl]ethanone.
3. Reactant for preparation of triazolothiadiazepine dioxide derivativesReactant for preparation of halo-substituted aromatic amidesReactant for preparation of [[(phenyl)piperazinyl]alkyl]indolyl]ethanone and [[[(phenoxyethyl)piperazinyl]alkyl]indolyl]ethanone derivatives as α1-adrenoreceptor antagonistsReactant for synthesis of naphthalenedione derivatives as antimycobacterial agentsReactant for regioselective ortho Suzuki-Miyaura coupling reaction

Synthesis Reference(s)

Tetrahedron, 52, p. 7525, 1996 DOI: 10.1016/0040-4020(96)00266-9Tetrahedron Letters, 24, p. 561, 1983 DOI: 10.1016/S0040-4039(00)81464-1

General Description

1-Acetylindoline, a substituted indole, is a tertiary amide having bulky N-groups. Its reduction to the corresponding amine, by reaction with silane in the presence of MoO2Cl2 (catalyst), has been reported.

Check Digit Verification of cas no

The CAS Registry Mumber 16078-30-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,0,7 and 8 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 16078-30:
(7*1)+(6*6)+(5*0)+(4*7)+(3*8)+(2*3)+(1*0)=101
101 % 10 = 1
So 16078-30-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO/c1-8(12)11-7-6-9-4-2-3-5-10(9)11/h2-5H,6-7H2,1H3

16078-30-1 Well-known Company Product Price

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  • Aldrich

  • (379492)  1-Acetylindoline  98%

  • 16078-30-1

  • 379492-5G

  • 391.95CNY

  • Detail

16078-30-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Acetylindoline

1.2 Other means of identification

Product number -
Other names 1-(2,3-dihydroindol-1-yl)ethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16078-30-1 SDS

16078-30-1Relevant articles and documents

Mild Rh(III)-catalyzed C7-allylation of indolines with allylic carbonates

Park, Jihye,Mishra, Neeraj Kumar,Sharma, Satyasheel,Han, Sangil,Shin, Youngmi,Jeong, Taejoo,Oh, Joa Sub,Kwak, Jong Hwan,Jung, Young Hoon,Kim, In Su

, p. 1818 - 1827 (2015)

The rhodium(III)-catalyzed direct allylation of indolines with allylic carbonates at room temperature is described. These transformations provide the facile and efficient construction of C7-allylated indolic scaffold.

A rapid and clean synthetic approach to cyclic peptides: Via micro-flow peptide chain elongation and photochemical cyclization: Synthesis of a cyclic RGD peptide

Mifune, Yuto,Nakamura, Hiroyuki,Fuse, Shinichiro

, p. 11244 - 11249 (2016)

A cyclic RGD peptide was efficiently synthesized based on micro-flow, triphosgene-mediated peptide chain elongation and micro-flow photochemical macrolactamization. Our approach enabled a rapid (amidation for peptide chain elongation 5 s, macrolactamization 5 min) and clean (only one column chromatographic separation) synthesis of a cyclic peptide.

Cobalt Catalyzed Hydroarylation of Michael Acceptors with Indolines Directed by a Weakly Coordinating Functional Group

Banjare, Shyam Kumar,Chebolu, Rajesh,Ravikumar

, p. 4049 - 4053 (2019)

A cobalt(III) catalyzed hydroarylation of Michael acceptors using indolines, selectively at the C-7 position, has been reported. For the selective C-7 functionalization of indoline, we have used a weakly coordinating amide carbonyl group. During the process of optimization, we have also discovered the unusual cocatalytic activity of zinc triflate in the C-H functionalization reaction. Hydroarylation of unprotected maleimide using indolines was a challenging substrate and never accomplished before, we were able to achieve this with our methodology in good yields.

A New Method for Preparation of 2-Aminopyridine:Borane and its Analogues

Okamoto, Yoshihisa,Osawa, Toshimitsu,Kinoshita, Toshio

, p. 462 - 464 (1982)

-

Preparation and catalytic evaluation of a palladium catalyst deposited over modified clinoptilolite (Pd&at;MCP) for chemoselective N-formylation and N-acylation of amines

Amirsoleimani, Mina,Khalilzadeh, Mohammad A.,Zareyee, Daryoush

, (2020/08/22)

Novel palladium nanoparticles stabilized by clinoptilolite as a natural inexpensive zeolite prepared and used for N-formylation and N-acylation of amines at room temperature at environmentally benign reaction conditions in good to excellent yields. Pd (II) was immobilized on the surface of clinoptilolite via facile multi-step amine functionalization to obtain a sustainable, recoverable, and highly active nano-catalyst. The structural and morphological characterizations of the catalyst carried out using XRD, FT-IR, BET and TEM techniques. Moreover, the catalyst is easily recovered using simple filtration and reused for 7 consecutive runs without any loss in activity.

Efficient synthesis process of medical intermediate 5-bromoindole

-

Paragraph 0036-0037; 0039; 0043-0044; 0046; 0050-0051; 0053, (2020/08/06)

The invention discloses an efficient synthesis process of a medical intermediate 5-bromoindole, comprising the following steps of: using an indole compound as a raw material, carrying out low-pressureliquid-phase hydrogenation to destroy five-membered ring conjugation of indole to obtain an indoline compound; enabling the indoline compound to react with an acylation reagent, and protecting nitrogen, so as to obtain an N-acyl indoline compound; carrying out bromination on the N-acyl indoline compound to obtain a 5-bromo-N-acyl indoline compound; carrying out deacylation protection on the 5-bromo-N-acyl indoline compound to obtain a 5-bromoindoline compound; and carrying out oxidative dehydrogenation on the 5-bromoindoline compound by using oxygen or air under the action of a cuprous catalyst and nitric oxide to obtain the target compound 5-bromoindole. The steps involved in the process are convenient to operate, the conditions are mild, and environmental pollution is reduced; finally,the prepared product is high in yield, high in purity and low in energy consumption.

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