163133-87-7Relevant articles and documents
Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases
Linz, Sabine,Mueller, Joerg,Huebner, Harald,Gmeiner, Peter,Troschuetz, Reinhard
experimental part, p. 4448 - 4458 (2009/12/04)
A series of phenylpiperazine-methyl-substituted 1H-pyrrolo[2,3-c]pyridine, imidazo[1,2-c]-, pyrrolo[2,3-d]- and pyrrolo[3,2-d]pyrimidines were prepared as selective dopamine D4-ligands. The pyrrolo[2,3-d]pyrimidine derivatives 12d (Ki = 1,9 nM)
CRF receptor antagonists and methods relating thereto
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, (2008/06/13)
CRF receptor antagonists are disclosed. Such receptor antagonists are thiadiazole-, pyrimidine-, triazine-, and triazole-containing compounds substituted with both a C3-C14 monocyclic or fused, homoaryl or heteroaryl group and a substituted amine group. The CFR receptor antagonists have utility in the treatment of a variety of disorders, including disorders associated with the hypersecretion of CRF.
Cephalosporin antibiotics
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, (2008/06/13)
The present invention relates to a cephalosporin compound represented by the following general formula (I): STR1 its pharmaceutically acceptable non-toxic salt, physiologically hydrolyzable ester, hydrate or solvate, or isomers thereof, in whichR 1 represents hydrogen or an amino-protecting group,R 2 and R 3 can be identical or different and independently of one another represent hydrogen or a hydroxy-protecting group, orR 2 and R 3 together can form a cyclic diol-protecting group,R 4 represents hydrogen or a carboxyl-protecting group,R 5, R 6 and R 7 independently of one another represent hydrogen, amino or substituted amino, hydroxy, alkoxy, C 1-4 alkyl, carboxyl or alkoxycarbonyl, orR 5 and R 6 together with the carbon atoms to which they are attached can form a C 3-7 cycle, andQ represents CH or N,and to a process for preparation thereof and a pharmaceutical composition containing the compound (I) as an active ingredient.
