165049-28-5

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• Basic information

  1. Product Name: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate
  2. Synonyms: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate;(S)-Diethyl 2-(4-(2-(2-aMino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioate 4-Methylbenzenesulfonate;N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-glutaMic acid;(2S)-2-{[4-(2-{2-aMino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioic acid;N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-glutaMic acid, 1,5-diethyl ester, 4-Methylbenzenesulfonate (1:1);(S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pe;PeMetrexed disodiuM INT-5;5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbaMoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-2-aMiniuM 4-Methylbenzenesulfonate (non-preferred naMe)
  3. CAS NO:165049-28-5
  4. Molecular Formula: C₇H₈O₃S*C₂₄H₂₉N₅O₆
  5. Molecular Weight: 655.725
  6. EINECS: 1806241-263-5
  7. Product Categories: N/A
  8. Mol File: 165049-28-5.mol
  9. Article Data: 9

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
  8. Solubility: Dichloromethane (Very Slightly), DMF (Slightly, Sonicated), DMSO (Slightly)
  9. CAS DataBase Reference: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate(CAS DataBase Reference)
  10. NIST Chemistry Reference: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate(165049-28-5)
  11. EPA Substance Registry System: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate(165049-28-5)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 165049-28-5(Hazardous Substances Data)

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165049-28-5 Suppliers

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• High quality N-[4-[2-(2-Amino-4,7-Dihydro-4-Oxo-3H-Pyrrolo[2,3-D]Pyrimidin-5-Yl)Ethyl]Benzoyl]L-Glutamic Acid, 1,5-Diethyl Ester, 4-Methylbenzenesulfonate (1:1) supplier in China

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• Simagchem Corporation
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• Factory Supply diethyl N-( {4-[2-(2-amino-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)]phenyl}carbonyl)-L-glutamate 4-methylbenzenesulfonate

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• Ality Chemical Corporation
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• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate

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• N-{4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoyl}L-glutamic acid diethyl ester 4-methylbenzenesulfonate

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• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate

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• TIANFUCHEM--165049-28-5 --N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate in stock

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• CAS 165049-28-5 Pemetrexed Disodium Intermediate

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• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate/ LIDE PHARMA- Factory supply / Best price

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• LIDE PHARMACEUTICALS LIMITED
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• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate

  Cas No: 165049-28-5

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165049-28-5 Usage

Chemical Properties

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Uses

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural mesothelioma (MPM).

Check Digit Verification of cas no

The CAS Registry Mumber 165049-28-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,0,4 and 9 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 165049-28:
(8*1)+(7*6)+(6*5)+(5*0)+(4*4)+(3*9)+(2*2)+(1*8)=135
135 % 10 = 5
So 165049-28-5 is a valid CAS Registry Number.

InChI:InChI=1/C24H29N5O6.C7H8O3S/c1-3-34-18(30)12-11-17(23(33)35-4-2)27-21(31)15-8-5-14(6-9-15)7-10-16-13-26-20-19(16)22(32)29-24(25)28-20;1-6-2-4-7(5-3-6)11(8,9)10/h5-6,8-9,13,17H,3-4,7,10-12H2,1-2H3,(H,27,31)(H4,25,26,28,29,32);2-5H,1H3,(H,8,9,10)/t17-;/m0./s1

165049-28-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	diethyl (2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate,4-methylbenzenesulfonic acid

1.2 Other means of identification

Product number	-
Other names	D-Pemetrexed Dimethyl Diester

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:165049-28-5 SDS

165049-28-5Upstream product

• 16450-41-2 L-glutamic acid diethyl ester 
• 104-15-4 toluene-4-sulfonic acid 
• 137281-39-1 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid 
• 1118-89-4 diethyl-L-glutamate hydrochloride 
• 1209465-70-2 C₂₀H₁₉N₇O₅ 
• 123910-88-3 methyl 4-(4-hydroxybut-1-yl)benzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 123910-86-1 4-(4-hydroxybut-1-ynyl)benzoic acid methyl ester 
• 155405-79-1 4-(3-bromo-4-oxobutyl)benzoic acid methyl ester 
• 106200-41-3 4-(4-carbomethoxyphenyl)butanal 
• 13107-55-6 D-glutamic acid diethyl ester 

165049-28-5Downstream Products

• 137281-23-3 pemetrexed 
• 869791-42-4 (2S)-2-[[4-[2-(2-amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid 

165049-28-5Relevant articles and documents

Method for preparing pemetrexed disodium at high yield

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Page/Page column 9-13, (2021/01/12)

The invention relates to a preparation method of pemetrexed disodium. The preparation method is characterized in that an alkali-modified microporous/mesoporous molecular sieve catalyst is used as a catalyst to replace NaOH as a reaction catalyst, so favorable yield and product purity are obtained under the condition of enlarged reaction scale.

Pemetrexed disodium intermediate and preparation method thereof

-

Paragraph 0085-0088, (2019/10/17)

The invention belongs to the technical field of medicines, and particularly relates to a pemetrexed disodium intermediate III-1 and a preparation method thereof. The preparation method includes the steps: taking 4-[2-(2-amino-4, 7-dihydro-4-oxygen-3H-pyrr

METHOD FOR PREPARING AN INTERMEDIATE FOR PRODUCING HIGH-PURITY PEMETREXED AND METHOD FOR PRODUCING HIGH-PURITY PEMETREXED USING THE INTERMEDIATE

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Paragraph 0079, (2016/08/17)

Disclosed are a method for preparing an intermediate for producing high-purity pemetrexed and a method for producing high-purity pemetrexed using the intermediate, and more specifically, a method for preparing pemetrexed diethyl ester, which is an intermediate for producing pemetrexed, or a salt thereof with high purity, and to a method for producing pemetrexed disodium salt with high purity using the intermediate.

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