166756-77-0Relevant articles and documents
A Highly Diastereoselective Synthesis of 4-Alkyl Threo Glutamic Acids
Gu, Zi-Qiang,Hesson, David P.
, p. 2101 - 2104 (1995)
Treatment of N-p-nitrobenzoyl L- or D-glutamic acid diester with lithium bis(trimethylsilyl)amide generates a chelated γ-enolate which reacts with alkyl halides to give (2S,4S)- or (2R,4R)-4-alkylated glutamic acid derivatives with very high diastereoselectivity.
Stereospecific Synthesis of 4-Alkylglutamates and 4-Alkylprolines
Moody, Claire M.,Young, Douglas W.
, p. 7277 - 7280 (2007/10/02)
Catalytic reduction of the 4-alkylidenepyroglutamate derivatives (3) affords an effective route to (2S,4S)-4-alkylglutamic acids and (2S,4S)-4-alkylprolines.The route has also been used to prepare a 4-alkylpyroglutamic acid derivative which is stereospeci