16727-44-9Relevant articles and documents
Reinvestigation of the synthesis of 1-deazauridine
Jen, Cheng-Hung,Chien, Tun-Cheng
, p. 523 - 534 (2010)
A thorough study for the synthesis of 1-deazauridine is described. 3-Bromo-2,6-dimethoxy-5-(-d-ribofuranosyl)pyridine, a synthetic precursor for 1-deazauridine, was prepared in seven steps from 2,6-dimethoxypyridine and d-ribose via the ribonolactone approach. Subsequent demethylation was unsuccessful but led to presumable anomerization and isomerization. The effort concluded that the synthesis of 1-deazauridine remained unachieved. Copyright Taylor and Francis Group, LLC.
The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents
Lam, Kim Hung,Gambari, Roberto,Yuen, Marcus Chun Wah,Kan, Chi Wai,Chan, Penni,Xu, Lijin,Tang, Weijun,Chui, Chung Hin,Cheng, Gregory Yin Ming,Wong, Raymond Siu Ming,Lau, Fung Yi,Tong, Cindy Sze Wai,Chan, Andrew Kit Wah,Lai, Paul Bo San,Kok, Stanton Hon Lung,Cheng, Chor Hing,Chan, Albert Sun Chi,Tang, Johnny Cheuk On
scheme or table, p. 2266 - 2269 (2009/12/25)
A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the prese
