173282-69-4Relevant articles and documents
Abnormal Nucleophilic Substitution in 3-Trichloromethylpyridine, its N-Oxide and 3,5-Bis(trichloromethyl)pyridine
Cartwright, David,Ferguson, John R.,Giannopoulos, Thomas,Varvounis, George,Wakefield, Basil J.
, p. 12791 - 12796 (1995)
The scope of abnormal reactions of nucleophiles with β-trichloromethylazines is further explored: reactions of 3-trichloromethylpyridine with nucleophiles other than methoxide, and reactions of 3-trichloromethylpyridine N-oxide and 3,5-bis(trichloromethyl)pyridine with methoxide.Attack at a ring carbon, followed by hydrogen migration to the side-chain, occured in most cases, though attack at the trichloromethyl carbon was also sometimes observed.
HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS
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Paragraph 0456-0457, (2020/07/16)
The present disclosure relates generally to compounds useful in treatment of conditions associated with mutant isocitrate dehydrogenase (mt-IDH), particularly mutant IDH1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against mutant IDH1 enzymes. Method of treating conditions associated with excessive activity of mutant IDH1 enzymes with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.
Pymetrozine derivative and its preparation method and application of parasite killing
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Sheet 0031; 0032; 0033; 0034, (2018/07/07)
The invention relates to a pymetrozine derivative (I) and a preparing method and insecticidal application thereof. According to a formula of the pymetrozine derivative (I), groups' meanings are shown in an instruction. The pymetrozine derivative (I) has excellent activity of killing aphids and insecticidal activity of killing mosquito larvae, cotton bollworms, European corn borers and armyworms.
