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17734-35-9

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17734-35-9 Usage

General Description

(4-methoxyphenyl)-N,N,N-trimethylmethanaminium is a chemical compound with the molecular formula C11H18NO. It is also known as methoxyphenyl trimethylammonium and is a quaternary ammonium salt. (4-methoxyphenyl)-N,N,N-trimethylmethanaminium is a white to off-white crystalline solid that is soluble in water and various organic solvents. It is commonly used in organic synthesis as a reagent for the methylation of certain compounds. Additionally, it has applications in pharmaceuticals and as a surfactant in various industrial processes. (4-methoxyphenyl)-N,N,N-trimethylmethanaminium should be handled and used with proper safety precautions and in accordance with relevant regulations and guidelines.

Check Digit Verification of cas no

The CAS Registry Mumber 17734-35-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,7,3 and 4 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 17734-35:
(7*1)+(6*7)+(5*7)+(4*3)+(3*4)+(2*3)+(1*5)=119
119 % 10 = 9
So 17734-35-9 is a valid CAS Registry Number.

17734-35-9Relevant articles and documents

A general and practical sulfonylation of benzylic ammonium salts with sulfonyl hydrazides for the synthesis of sulfones

Zhu, Haibo,Zhang, Yingying,Liu, Yishuai,Yang, Liu,Xie, Zongbo,Jiang, Guofang,Le, Zhang-Gao

supporting information, (2020/05/06)

A practical and efficient approach adopting transition-metal-free cross-coupling of sulfonyl hydrazides with benzyl ammonium salts has been developed to synthesize benzyl sulfones using Cs2CO3 as base under mild conditions. The protocol employs stable and easy to handle coupling partners, and is endowed with good substrate compatibility, leading to functional benzyl sulfones in good yields.

8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists

Gilligan, Paul J.,He, Liqi,Clarke, Todd,Tivitmahaisoon, Parcharee,Lelas, Snjezana,Li, Yu-Wen,Heman, Karen,Fitzgerald, Lawrence,Miller, Keith,Zhang, Ge,Marshall, Anne,Krause, Carol,McElroy, John,Ward, Kathyrn,Shen, Helen,Wong, Harvey,Grossman, Scott,Nemeth, Gregory,Zaczek, Robert,Arneric, Stephen P.,Hartig, Paul,Robertson, David W.,Trainor, George

scheme or table, p. 3073 - 3083 (2010/01/16)

This report describes the syntheses and structure-activity relationships of 8-(4-methoxyphenyl)pyrazolo-[1,5-a]-1,3,5-triazine corticotropin releasing factor receptor-1 (CRF1) receptor antagonists. CRF1 receptor antagonists may be potential anxiolytic or antidepressant drugs. This research culminated in the discovery of analogue 12-3, which is a potent, selective CRF1 antagonist (hCRF1 IC50 ) 4.7 ± 2.0 nM) with weak affinity for the CRF-binding protein and biogenic amine receptors. This compound also has a good pharmacokinetic profile in dogs. Analogue 12-3 is orally effective in two rat models of anxiety: the defensive withdrawal (situational anxiety) model and the elevated plus maze test. Analogue 12-3 has been advanced to clinical trials.

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