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178209-28-4

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178209-28-4 Usage

General Description

6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-3-amine, also known as THP, is a chemical compound that belongs to the class of heterocyclic amines. It is a bicyclic organic compound with a seven-membered ring structure containing a nitrogen atom. This chemical is used in the synthesis of various pharmaceuticals, such as antimalarial and anticancer drugs. It has also been investigated for its potential as a neuromodulator and for its ability to modulate neurotransmitter release. THP has shown promising results in research studies for its pharmacological and therapeutic properties, making it a valuable compound in the field of medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 178209-28-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,8,2,0 and 9 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 178209-28:
(8*1)+(7*7)+(6*8)+(5*2)+(4*0)+(3*9)+(2*2)+(1*8)=154
154 % 10 = 4
So 178209-28-4 is a valid CAS Registry Number.

178209-28-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 6,7,8,9-Tetrahydro-5H-cyclohepta[b]pyridin-3-amine

1.2 Other means of identification

Product number -
Other names 5H-Cyclohepta[b]pyridin-3-amine,6,7,8,9-tetrahydro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:178209-28-4 SDS

178209-28-4Downstream Products

178209-28-4Relevant articles and documents

Synthesis and structure-activity relationships of fused imidazopyridines: A new series of benzodiazepine receptor ligands

Takada, Susumu,Sasatani, Takashi,Chomei, Nobuo,Adachi, Makoto,Fujishita, Toshio,Eigyo, Masami,Murata, Shunji,Kawasaki, Kazuo,Matsushita, Akira

, p. 2844 - 2851 (2007/10/03)

2-Arylimidazo[4,5-c]quinolines and analogous fused imidazopyridines were synthesized and evaluated as benzodiazepine receptor ligands. Affinity to the receptors was greatly affected by the bulkiness of the aryl group at the 2- position, compared to the pyrazoloquinolines such as CGS-9896. Derivatives with an isoxazole moiety at the 2-position showed high binding affinity and in vivo activity. In the imidazo[4,5-c]quinoline series, substitution at the 6-position decreased or abolished activity. Most derivatives with an unsubstituted isoxazolyl group showed antagonist or inverse agonist activity except for the 7-halo analogues, which exhibited agonist activity. On the other hand, 5-methylisoxazol-3-yl or 3-methylisoxazol-5-yl derivatives generally exhibited agonist activity. A similar substitution effect on the isoxazole moiety was observed in the imidazopyridines fused with a nonaromatic ring. From the detailed pharmacological evaluation, S-8510, 2- (3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine monophosphate, possessing weak inverse agonist activity was selected as a therapeutic candidate for the treatment of some symptoms of senile dementia.

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