180526-67-4

• 

• Basic information

  1. Product Name: 2-Propenamide,3-(4-pyridinyl)-,(E)-(9CI)
  2. Synonyms: 2-Propenamide,3-(4-pyridinyl)-,(E)-(9CI)
  3. CAS NO:180526-67-4
  4. Molecular Formula: C8H8N2O
  5. Molecular Weight: 148.16
  6. EINECS: N/A
  7. Product Categories: PYRIDINE
  8. Mol File: 180526-67-4.mol
  9. Article Data: 2

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: 2-Propenamide,3-(4-pyridinyl)-,(E)-(9CI)(CAS DataBase Reference)
  10. NIST Chemistry Reference: 2-Propenamide,3-(4-pyridinyl)-,(E)-(9CI)(180526-67-4)
  11. EPA Substance Registry System: 2-Propenamide,3-(4-pyridinyl)-,(E)-(9CI)(180526-67-4)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 180526-67-4(Hazardous Substances Data)

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• 2-PROPENAMIDE,3-(PYRIDIN-4-YL)-,(E)-

  Cas No: 180526-67-4

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180526-67-4 Usage

Molecular weight

148.16 g/mol

Also known as

3-Acrylamidopyridine

Classification

Acrylamide derivative

Physical properties

Pale yellow liquid, Boiling point of 305°C, Density of 1.119 g/mL at 25°C

Applications

Intermediate in the synthesis of pharmaceuticals and agrochemicals, Potential applications in organic synthesis and materials science

Safety precautions

May cause skin and eye irritation, Harmful if swallowed or inhaled.

Check Digit Verification of cas no

The CAS Registry Mumber 180526-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,5,2 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 180526-67:
(8*1)+(7*8)+(6*0)+(5*5)+(4*2)+(3*6)+(2*6)+(1*7)=134
134 % 10 = 4
So 180526-67-4 is a valid CAS Registry Number.

180526-67-4Upstream product

• 15854-87-2 4-iodopyridine 
• 79-06-1 2-propenamide 

180526-67-4Downstream Products

180526-67-4Relevant articles and documents

Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Russo, Francesco,Gising, Johan,?kerbladh, Linda,Roos, Annette K.,Naworyta, Agata,Mowbray, Sherry L.,Sokolowski, Anders,Henderson, Ian,Alling, Torey,Bailey, Mai A.,Files, Megan,Parish, Tanya,Karlén, Anders,Larhed, Mats

, p. 342 - 362 (2015/06/30)

This is the first report of 5-styryl-oxathiazol-2-ones as inhibitors of the Mycobacterium tuberculosis (Mtb) proteasome. As part of the study, the structure-activity relationship of oxathiazolones as Mtb proteasome inhibitors has been investigated. Furthermore, the prepared compounds displayed a good selectivity profile for Mtb compared to the human proteasome. The 5-styryl-oxathiazol-2-one inhibitors identified showed little activity against replicating Mtb, but were rapidly bactericidal against nonreplicating bacteria. (E)-5-(4-Chlorostyryl)-1,3,4-oxathiazol-2-one) was most effective, reducing the colony-forming units (CFU)/mL below the detection limit in only seven days at all concentrations tested. The results suggest that this new class of Mtb proteasome inhibitors has the potential to be further developed into novel antitubercular agents for synergistic combination therapies with existing drugs.

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