182344-25-8Relevant articles and documents
4-fluoronaphthalene-1-alcohol preparation technology
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Paragraph 0043; 0044; 0045; 0067; 0068; 0069, (2017/08/26)
The invention discloses a 4-fluoronaphthalene-1-alcohol preparation technology. The preparation technology takes 1-fluoronaphthalene as a raw material, the raw material is subjected to halogenation, boration and hydrolysis to obtain the 4-fluoronaphthalene-1-alcohol, and the overall yield can reach 60%. The technology has the advantages of low cost and easy acquisition of the raw materials, simple and easy operation of post-treatment t, high yield, and easy industrial application.
Structure-Activity Relationships of Potent, Selective Inhibitors of Neuronal Nitric Oxide Synthase Based on the 6-Phenyl-2-aminopyridine Structure
Lowe III, John A.,Qian, Weimin,Drozda, Susan E.,Volkmann, Robert A.,Nason, Deane,Nelson, Robert B.,Nolan, Charles,Liston, Dane,Ward, Karen,Faraci, Steve,Verdries, Kim,Seymour, Pat,Majchrzak, Michael,Villalobos, Anabella,White, W. Frost
, p. 1575 - 1586 (2007/10/03)
The synthesis and structure-activity relationships of a series of 6-phenyl-2-aminopyridines that potently and selectively inhibit the neuronal isoform of nitric oxide synthase (nNOS) are described. Compound 14bi from this series exhibits potent in vivo activity in harmaline-induced cGMP formation in rat cerebellum, a functional model of nNOS inhibition, and in the PCP-induced hypermotility model in the rat. These results suggest that 14bi may be a useful reagent for evaluating potential therapeutic applications of nNOS inhibitors in the central nervous system.
2-aminopyridines containing fused ring substituents
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, (2008/06/13)
The present invention relates to 2-aminopyridine derivatives of the formula wherein G, R1 and R2 are defined as in the specification, that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system and other disorders.