185028-75-5

• 

• Basic information

  1. Product Name: 4H-Naphtho[1,2-b]pyran-4-one,2-(3-aminophenyl)-(9CI)
  2. Synonyms: 4H-Naphtho[1,2-b]pyran-4-one,2-(3-aminophenyl)-(9CI)
  3. CAS NO:185028-75-5
  4. Molecular Formula: C19H13NO2
  5. Molecular Weight: 287.31202
  6. EINECS: N/A
  7. Product Categories: FLAVONE
  8. Mol File: 185028-75-5.mol
  9. Article Data: 1

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: 4H-Naphtho[1,2-b]pyran-4-one,2-(3-aminophenyl)-(9CI)(CAS DataBase Reference)
  10. NIST Chemistry Reference: 4H-Naphtho[1,2-b]pyran-4-one,2-(3-aminophenyl)-(9CI)(185028-75-5)
  11. EPA Substance Registry System: 4H-Naphtho[1,2-b]pyran-4-one,2-(3-aminophenyl)-(9CI)(185028-75-5)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 185028-75-5(Hazardous Substances Data)

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185028-75-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 185028-75-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,0,2 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 185028-75:
(8*1)+(7*8)+(6*5)+(5*0)+(4*2)+(3*8)+(2*7)+(1*5)=145
145 % 10 = 5
So 185028-75-5 is a valid CAS Registry Number.

185028-75-5Upstream product

• 99-05-8 meta-aminobenzoic acid 
• 111331-82-9 3-[(tert-butoxycarbonyl)amino]benzoic acid 

185028-75-5Downstream Products

185028-75-5Relevant articles and documents

Design and synthesis of selective CYP1B1 inhibitor via dearomatization of α-naphthoflavone

Kubo, Makoto,Yamamoto, Keiko,Itoh, Toshimasa

, p. 285 - 304 (2019)

Selective cytochrome P450 (CYP) 1B1 inhibition has potential as an anticancer strategy that is unrepresented in the current clinical arena. For development of a selective inhibitor, we focused on the complexity caused by sp3-hybridized carbons and synthesized a series of benzo[h]chromone derivatives linked to a non-aromatic B-ring using α-naphthoflavone (ANF) as the lead compound. Ring structure comparison suggested compound 37 as a suitable cyclohexyl-core with improved solubility. Structural evolution of 37 produced the azide-containing cis-49a, which had good properties in three important respects: (1) selectivity for CYP1B1 over CYP1A1 and CYP1A2 (120-times and 150-times, respectively), (2) greater inhibitory potency of >2 times that of ANF, and (3) improved solubility. The corresponding aromatic B-ring compound 59a showed low selectivity and poor solubility. To elucidate the binding mode, we performed X-ray crystal structure analysis, which revealed the interaction mode and explained the subtype selectivity of cis-49a.

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