18505-91-4

• 

• Basic information

  1. Product Name: (2,3-DIHYDRO-BENZO[1,4]DIOXIN-2-YL)-ACETONITRILE
  2. Synonyms: (2,3-DIHYDRO-BENZO[1,4]DIOXIN-2-YL)-ACETONITRILE;2,3-dihydro-1,4-benzodioxin-2-ylacetonitrile;2,3-dihydro-1,4-Benzodioxin-2-acetonitrile
  3. CAS NO:18505-91-4
  4. Molecular Formula: C₁₀H₉NO₂
  5. Molecular Weight: 175.18396
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 18505-91-4.mol
  9. Article Data: 17

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 326.7 °C at 760 mmHg
  3. Flash Point: 137.5 °C
  4. Appearance: /
  5. Density: 1.173 g/cm³
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: (2,3-DIHYDRO-BENZO[1,4]DIOXIN-2-YL)-ACETONITRILE(CAS DataBase Reference)
  10. NIST Chemistry Reference: (2,3-DIHYDRO-BENZO[1,4]DIOXIN-2-YL)-ACETONITRILE(18505-91-4)
  11. EPA Substance Registry System: (2,3-DIHYDRO-BENZO[1,4]DIOXIN-2-YL)-ACETONITRILE(18505-91-4)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 18505-91-4(Hazardous Substances Data)

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• SDS
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• (2,3-Dihydrobenzo[1,4]dioxin-2-yl)acetonitrile

  Cas No: 18505-91-4

• USD $ 3.0-3.0 / Kilogram

• 1 Kilogram

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• Dayang Chem (Hangzhou) Co.,Ltd.
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• High quality 2-(2,3-Dihydrobenzo[B][1,4]Dioxin-2-Yl)Acetonitrile supplier in China

  Cas No: 18505-91-4

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• 2-(2,3-Dihydrobenzo[B][1,4]Dioxin-2-Yl)Acetonitrile

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• Xiamen Hisunny Chemical Co.,Ltd
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• 2-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)acetonitrile

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• Hangzhou J&H Chemical Co., Ltd.
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• (2,3-Dihydrobenzo[1,4]dioxin-2-yl)acetonitrile

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• Zibo Hangyu Biotechnology Development Co., Ltd
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• 2-(2,3-Dihydrobenzo[B][1,4]Dioxin-2-Yl)Acetonitrile

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• Aecochem Corp.
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• (2,3-Dihydrobenzo[1,4]dioxin-2-yl)acetonitrile

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• (2,3-Dihydrobenzo[1,4]dioxin-2-yl)acetonitrile cas 18505-91-4

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• Hangzhou Fandachem Co.,Ltd
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• (2,3-DIHYDRO-BENZO[1,4]DIOXIN-2-YL)-ACETONITRILE

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• ZHEJIANG JIUZHOU CHEM CO.,LTD
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• Hot Sale 2-(2,3-Dihydrobenzo[B][1,4]Dioxin-2-Yl)Acetonitrile

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18505-91-4 Usage

General Description

(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-acetonitrile is a chemical compound that contains a dioxin ring structure and an acetonitrile functional group. Dioxins are highly toxic and are known to be persistent organic pollutants that can have harmful effects on human health and the environment. Acetonitrile is a common solvent and intermediate in organic synthesis, but it can also be toxic in high concentrations. The exact properties and potential hazards of this specific compound have not been extensively studied, but as a dioxin-containing compound, it should be handled with caution and proper safety measures. Further research and testing would be needed to fully understand the potential risks associated with this chemical.

Check Digit Verification of cas no

The CAS Registry Mumber 18505-91-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,5,0 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 18505-91:
(7*1)+(6*8)+(5*5)+(4*0)+(3*5)+(2*9)+(1*1)=114
114 % 10 = 4
So 18505-91-4 is a valid CAS Registry Number.

InChI:InChI=1/C10H9NO2/c11-6-5-8-7-12-9-3-1-2-4-10(9)13-8/h1-4,8H,5,7H2

18505-91-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name	2-(2,3-dihydro-1,4-benzodioxin-3-yl)acetonitrile

1.2 Other means of identification

Product number	-
Other names	2-cyanomethyl-2,3-dihydro-1,4-benzodioxin

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18505-91-4 SDS

18505-91-4Upstream product

• 1094-91-3 2-(toluene-4-sulfonyloxymethyl)-2,3-dihydro-benzo[1,4]dioxine 
• 151-50-8 potassium cyanide 
• 2164-34-3 2-(bromomethyl)-2,3-dihydrobenzo[1,4]dioxine 
• 25109-74-4 3,4-dibromobutyronitrile 
• 120-80-9 benzene-1,2-diol 
• 109-75-1 but-3-enenitrile 
• 3663-82-9 2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin 
• 4739-94-0 ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate 
• 143-33-9 sodium cyanide 

18505-91-4Downstream Products

• 87086-36-0 2-(2,3-dihydrobenzo[1,4]dioxin-2-yl)ethylamine 
• 81403-81-8 1-benzyl-2-(1,4-benzodioxan-2-ylmethyl)imidazole 
• 81167-16-0 imiloxan 
• 18505-92-5 2-Carboxymethyl-2,3-dihydro-1,4-benzodioxin 

18505-91-4Relevant articles and documents

Novel, broad-spectrum anticonvulsants containing a sulfamide group: Pharmacological properties of (S)- N -[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2- yl)methyl]sulfamide (JNJ-26489112)

McComsey, David F.,Smith-Swintosky, Virginia L.,Parker, Michael H.,Brenneman, Douglas E.,Malatynska, Ewa,White, H. Steve,Klein, Brian D.,Wilcox, Karen S.,Milewski, Michael E.,Herb, Mark,Finley, Michael F. A.,Liu, Yi,Lubin, Mary Lou,Qin, Ning,Reitz, Allen B.,Maryanoff, Bruce E.

, p. 9019 - 9030 (2014/01/06)

Broad-spectrum anticonvulsants are of considerable interest as antiepileptic drugs, especially because of their potential for treating refractory patients. Such "neurostabilizers" have also been used to treat other neurological disorders, including migraine, bipolar disorder, and neuropathic pain. We synthesized a series of sulfamide derivatives (4-9, 10a-i, 11a, 11b, 12) and evaluated their anticonvulsant activity. Thus, we identified promising sulfamide 4 (JNJ-26489112) and explored its pharmacological properties. Compound 4 exhibited excellent anticonvulsant activity in rodents against audiogenic, electrically induced, and chemically induced seizures. Mechanistically, 4 inhibited voltage-gated Na+ channels and N-type Ca2+ channels and was effective as a K+ channel opener. The anticonvulsant profile of 4 suggests that it may be useful for treating multiple forms of epilepsy (generalized tonic-clonic, complex partial, absence seizures), including refractory (or pharmacoresistant) epilepsy, at dose levels that confer a good safety margin. On the basis of its pharmacology and other favorable characteristics, 4 was advanced into human clinical studies.

USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN

-

Page/Page column 17, (2008/06/13)

The present invention is a method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as desc

CO-THERAPY FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS

-

Page/Page column 41-42, (2008/06/13)

The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative

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