185553-96-2Relevant articles and documents
NMR Spectroscopic Determination of the Solution Structure of a Branched Nucleic Acid from Residual Dipolar Couplings by Using Isotopically Labeled Nucleotides
Van Buuren, Bernd N. M.,Schleucher, Juergen,Wittmann, Valentin,Griesinger, Christian,Schwalbe, Harald,Wijmenga, Sybren S.
, p. 187 - 192 (2007/10/03)
Only a small set of magnetic-field-induced residual dipolar couplings is required to determine the global structure of branched nucleic acids. This is demonstrated for the example of the Holliday junction (shown schematically) after 13C labelin
Synthesis of (5'S)-1;1',2',3',4',5'-13C5>-Thymidine via Stereoselective Deuteration of a 5-Oxoribose Derivative
Ono, Akira (Mei),Ono, Akira,Kainosho, Masatsune
, p. 395 - 398 (2007/10/03)
(5'S)-1:1',2'3'4'5'-13C5>-Thymidine has been synthesized by a stereoselective deuteride transfer reaction from (-)- or (+)-1>-isobornyloxymagnesium bromide to a 5-oxoribose derivative, which can be readily prepared from 6>-D-glucose.The overall yield from D-glucose to thymidine was 27percent.The various nucleosides with a stereoselective 2H-label together with 13C at the C5' position, which have become available by the present method, will be quite useful for stereospecific assignment of the diastereotopic C5' methylene signals, and also for conformational analyses of the O5'-C5' bonds in nucleic acid oligomers.
