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18594-05-3

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18594-05-3 Usage

Chemical Properties

white to yellow crystalline powder

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1105, 1946 DOI: 10.1021/ja01210a059

General Description

Antimycobacterial activity of 4-cyclohexylacetophenone was studied. The tricarbonylchromium complexes of 4-cyclohexylacetophenone were prepared and spectral properties were studied.

Check Digit Verification of cas no

The CAS Registry Mumber 18594-05-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,5,9 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 18594-05:
(7*1)+(6*8)+(5*5)+(4*9)+(3*4)+(2*0)+(1*5)=133
133 % 10 = 3
So 18594-05-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H18O/c1-11(15)12-7-9-14(10-8-12)13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3

18594-05-3 Well-known Company Product Price

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  • Alfa Aesar

  • (B20838)  4'-Cyclohexylacetophenone, 99%   

  • 18594-05-3

  • 5g

  • 316.0CNY

  • Detail
  • Alfa Aesar

  • (B20838)  4'-Cyclohexylacetophenone, 99%   

  • 18594-05-3

  • 25g

  • 674.0CNY

  • Detail
  • Alfa Aesar

  • (B20838)  4'-Cyclohexylacetophenone, 99%   

  • 18594-05-3

  • 100g

  • 1771.0CNY

  • Detail

18594-05-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-cyclohexylphenyl)ethanone

1.2 Other means of identification

Product number -
Other names 4'-Cyclohexylacetophenone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18594-05-3 SDS

18594-05-3Relevant articles and documents

Study on the design, synthesis and structure-activity relationships of new thiosemicarbazone compounds as tyrosinase inhibitors

Song, Senchuan,You, Ao,Chen, Zhiyong,Zhu, Guoxun,Wen, Huan,Song, Huacan,Yi, Wei

, p. 815 - 825 (2017)

52 Structure-based thiosemicarbazone compounds bearing various substituted-lipophilic part, including substituted-benzaldehyde, substituted-phenylalkan-1-one and their biphenyl-type thiosemicarbazone analogs, were designed, synthesized and evaluated as new tyrosinase inhibitors. The results demonstrated that 22 compounds have potent inhibitory activities against tyrosinase with the IC50 value of lower than 1.0 μM. On the basis of the obtained experimental data, the structure-activity relationships (SARs) were rationally derived. Besides, the inhibition mechanism and the inhibitory kinetics of selected compounds 3d and 6e were investigated, revealing that such type of compounds were belonged to the reversible and competitive tyrosinase inhibitors. To verify the safety of these developed thiosemicarbazone compounds, four randomly selected compounds 3d, 4e, 6a and 9a were also tested in 293T cell line for the evaluation of the cytotoxicity. Interestingly, all these compounds almost did not perform any toxicity to 293T cells even at a high concentration of 1000 μmol/L. Taken together, these results suggested that such compounds could serve as the highly efficient and more safe candidates for the treatment of tyrosinase-related disorders.

Dealkenylative Ni-Catalyzed Cross-Coupling Enabled by Tetrazine and Photoexcitation

Cao, Yuhui,Che, Jinteng,Chen, Han,Chen, Si-Cong,Fang, Xianhe,Guo, Yinliang,Guo, Zhixian,Kong, Lingran,Li, Chen,Lu, Jia-Tian,Luo, Tuoping,Zhang, Nan,Zhu, Qi

, p. 14046 - 14052 (2021/09/13)

A new and general method to functionalize the C(sp3)-C(sp2) bond of alkyl and alkene linkages has been developed, leading to the dealkenylative generation of carbon-centered radicals that can be intercepted to undergo Ni-catalyzed C(sp3)-C(sp2) cross-coupling. This one-pot protocol leverages the easily procured alkene feedstocks for organic synthesis with excellent functional group compatibility without the need for a photoredox catalyst.

Nickel-Catalyzed, para-Selective, Radical-Based Alkylation of Aromatic Ketones

Wang, Jie,Pang, Yu-Bo,Tao, Na,Zeng, Runsheng,Zhao, Yingsheng

supporting information, p. 854 - 857 (2020/01/31)

A direct, para-selective, radical-based alkylation of aromatic ketones with alkanes has been developed using a nickel catalyst with oxamide as the ligand. Acetophenones bearing electron-withdrawing substituents were functionalized directly with simple alkanes with high para-selectivity while acetophenones with electron-donating groups were mainly para-functionalized. A mechanistic study indicated that C-H bond activation of the aromatic ring may be the rate-determining step of the reaction.

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