18636-88-9

• 

• Basic information

  1. Product Name: BENZO(A)PHENAZINE-DI-N-OXIDE
  2. Synonyms: BENZO(A)PHENAZINE-DI-N-OXIDE;Benzo[a]phenazine 7,12-dioxide
  3. CAS NO:18636-88-9
  4. Molecular Formula: C16H10 N2 O2
  5. Molecular Weight: 272.38
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 18636-88-9.mol
  9. Article Data: 2

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: °Cat760mmHg
  3. Flash Point: °C
  4. Appearance: /
  5. Density: g/cm³
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: BENZO(A)PHENAZINE-DI-N-OXIDE(CAS DataBase Reference)
  10. NIST Chemistry Reference: BENZO(A)PHENAZINE-DI-N-OXIDE(18636-88-9)
  11. EPA Substance Registry System: BENZO(A)PHENAZINE-DI-N-OXIDE(18636-88-9)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 18636-88-9(Hazardous Substances Data)

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• Benzo[a]phenazine,7,12-dioxide

  Cas No: 18636-88-9

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• 10 Gram

• 500 Kilogram/Month

• Zibo Hangyu Biotechnology Development Co., Ltd
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• Benzo[a]phenazine,7,12-dioxide

  Cas No: 18636-88-9

• No Data

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18636-88-9 Usage

Safety Profile

Low toxicity by ingestion. Whenheated to decomposition it emits toxic vapors of NOx.

Check Digit Verification of cas no

The CAS Registry Mumber 18636-88-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,3 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18636-88:
(7*1)+(6*8)+(5*6)+(4*3)+(3*6)+(2*8)+(1*8)=139
139 % 10 = 9
So 18636-88-9 is a valid CAS Registry Number.

InChI:InChI=1/C16H10N2O2/c19-17-13-7-3-4-8-14(13)18(20)16-12-6-2-1-5-11(12)9-10-15(16)17/h1-10H

18636-88-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	7-oxidobenzo[a]phenazin-12-ium 12-oxide

1.2 Other means of identification

Product number	-
Other names	Benzo<a>phenazin-N,N-dioxyd

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18636-88-9 SDS

18636-88-9Upstream product

• 480-96-6 benzofurazan oxide 
• 90-15-3 α-naphthol 
• 91-59-8 naphthalen-2-ylamine 
• 98-95-3 nitrobenzene 
• 88-74-4 2-nitro-aniline 
• 135-19-3 β-naphthol 
• 18636-87-8 benzo[a]phenazine 12-oxide 

18636-88-9Downstream Products

• 18636-86-7 Benzo -phenazin-7-oxid 

18636-88-9Relevant articles and documents

Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation

Lavaggi, Maria Laura,Cabrera, Mauricio,Aravena, Maria de los Angeles,Olea-Azar, Claudio,Lopez de Cerain, Adela,Monge, Antonio,Pachon, Gisela,Cascante, Marta,Bruno, Ana Maria,Pietrasanta, Lia I.,Gonzalez, Mercedes,Cerecetto, Hugo

, p. 4433 - 4440 (2010)

Phenazine 5,10-dioxides are prodrugs for antitumor therapy that undergo hypoxic-selective bioreduction to form cytotoxic species. Here we investigate the expanded system benzo[a]phenazine 7,12-dioxides as selective hypoxic cytotoxin-scaffold. The clonogenic survival of V79 cells on aerobic and anaerobic conditions, conduct us to study antiproliferative activity on Caco-2 tumoral cells in normoxia. Electrochemical, DNA-interaction and DNA-damage studies were performed to establish the mode of action. The results demonstrated the potential biological properties of the studied scaffold being derivatives 6-10 structural hits for further chemical-modifications to become into therapeutics for solid tumors. Compounds 6 and 8 with cytotoxicity against V79 cells in both conditions (aerobia and anaerobia) were also cytotoxic against Caco-2 tumoral cells in aerobiosis.

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