18711-16-5

• 

• Basic information

  1. Product Name: NS309
  2. Synonyms: 6,7-Dichloro-1H-indole-2,3-dione3-oxime;1H-Indole-2,3-dione,6,7-dichloro-, 3-oxiMe;6,7-Dichloroindole-2,3-dione 3-oxime;6,7-Dichloroisatin 3-oxime;6,7-Dichloro-3-(hydroxyiMino)indolin-2-one
  3. CAS NO:18711-16-5
  4. Molecular Formula: C8H4Cl2N2O2
  5. Molecular Weight: 231.038
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 18711-16-5.mol
  9. Article Data: 1

• Chemical Properties

  1. Melting Point: 190-192℃
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: yellow/solid
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: 2-8°C
  8. Solubility: DMSO: ~22 mg/mL
  9. CAS DataBase Reference: NS309(CAS DataBase Reference)
  10. NIST Chemistry Reference: NS309(18711-16-5)
  11. EPA Substance Registry System: NS309(18711-16-5)

• Safety Data

  1. Hazard Codes: Xi
  2. Statements: 36/37/38
  3. Safety Statements: 26-36
  4. WGK Germany: 2
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 18711-16-5(Hazardous Substances Data)

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18711-16-5 Suppliers

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  Cas No: 18711-16-5

• USD $ 139.0-210.0 / Kilogram

• 1 Kilogram

• 1000 Kilogram/Day

• Zhuozhou Wenxi import and Export Co., Ltd
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• 6,7-Dichloro-1H-indole-2,3-dione-3-oxime

  Cas No: 18711-16-5

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• Dayang Chem (Hangzhou) Co.,Ltd.
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• NS309 cas 18711-16-5

  Cas No: 18711-16-5

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• 100 Milligram

• 300 Gram/Month

• Taizhou Crene Biotechnology co.ltd
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• 6,7-Dichloro-1H-indole-2,3-dione 3-oxime

  Cas No: 18711-16-5

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• Suzhou Health Chemicals Co., Ltd.
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• 3-Oxime-6,7-dichloro-1H-indole-2,3-dione

  Cas No: 18711-16-5

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• Kono Chem Co.,Ltd
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• 1H-Indole-2,3-dione,6,7-dichloro-, 3-oxime

  Cas No: 18711-16-5

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• Hangzhou Dingyan Chem Co., Ltd
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• 3-OxiMe-6,7-dichloro-1H-indole-2,3-dione

  Cas No: 18711-16-5

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• Antimex Chemical Limied
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• NS309 CAS No.18711-16-5

  Cas No: 18711-16-5

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• Guangdong Juda Chemical Industrial Co.,Limited
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• 6,7-Dichloroisatin 3-oxime

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• SAGECHEM LIMITED
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• NS309

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• BOC Sciences
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18711-16-5 Usage

Uses

NS 309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels.

Biological Activity

Positive modulator of small- and intermediate- conductance Ca 2+ -activated K + channels (SK and IK channels); increases Ca 2+ sensitivity. Displays no activity at BK channels.

Biochem/physiol Actions

NS309 is a Ca2+-activated IK/SK potassium channel activator.

Check Digit Verification of cas no

The CAS Registry Mumber 18711-16-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,7,1 and 1 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18711-16:
(7*1)+(6*8)+(5*7)+(4*1)+(3*1)+(2*1)+(1*6)=105
105 % 10 = 5
So 18711-16-5 is a valid CAS Registry Number.

18711-16-5 Well-known Company Product Price

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• Sigma

• (N8161)  NS309  ≥98% (HPLC), solid

• 18711-16-5

• N8161-5MG

• 1,325.61CNY

• Detail

• Sigma

• (N8161)  NS309  ≥98% (HPLC), solid

• 18711-16-5

• N8161-25MG

• 5,296.59CNY

• Detail

18711-16-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name	6,7-dichloro-3-(hydroxyamino)indol-2-one

1.2 Other means of identification

Product number	-
Other names	NS-309

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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18711-16-5Related news

Investigative urologyUrodynamic Effects of Intravesical Administration of the New Small/Intermediate Conductance Calcium Activated Potassium Channel Activator NS309 (cas 18711-16-5) in Freely Moving, Conscious Rats09/25/2019

PurposeWe investigated the effects of the new K+ channel activator NS309, which acts on small and intermediate conductance Ca2+ activated K+ channels, on detrusor activity in normal rats.detailed

18711-16-5Relevant articles and documents

Use of isatin derivatives as ion channel activating agents

-

, (2008/06/13)

The present invention relates to ion channel activating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as openers of SKCa and IKCa channels. In further aspects, the present invention relates to the use of these SK/IK channel activating agents for the manufacture of medicaments and pharmaceutical compositions comprising the SK/IK channel activating agents. The SK/IK channel activating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK channels, in particular respiratory diseases such as asthma, cystic fibrosis, chronic obstructive pulmonary disease and rhinorrhea, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, traumatic brain injury, psychosis, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labor, baldness, cancer, and immune suppression.

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