191474-79-0Relevant articles and documents
Synthesis and in vitro antitumour evaluation of benzothiazole-2- carbonitrile derivatives
Beneteau, Valerie,Besson, Thierry,Guillard, Jerome,Leonce, Stephane,Pfeiffer, Bruno
, p. 1053 - 1060 (1999)
Novel benzothiazole derivatives have been synthesised via the corresponding imino-1,2,3-dithiazoles. The cytotoxicity of some of these polyheterocyclic compounds was studied. Our results show that 2-cyano derivatives exhibit a medium in vitro antitumour a
Eco-Friendly Microwave-Assisted Scaleable Synthesis of 2-Cyanobenzothiazoles via N-Arylimino-1,2,3-dithiazoles
Frere, Stephane,Thiery, Valerie,Besson, Thierry
, p. 3795 - 3804 (2007/10/03)
The cyclization procedure of N-aryl iminodithiazoles into 2-cyanobenzothiazoles was re-investigated with the aim to develop original and environmentally friendly procedures. In this article, the benefits associated with the microwave methodology are reported and the opportunity to use solvent-free procedures in order to scale up organic synthesis is studied. The result obtained show that the strong thermal effects due to graphite/microwaves interaction can be efficiently used for the synthesis of heterocyclic molecules for which traditional methods failed or are less attractive.