191480-69-0Relevant articles and documents
Preparation method of entecavir intermediate
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Paragraph 0031-0033; 0037-0039; 0043-0045, (2021/06/26)
The invention provides a preparation method of an entecavir intermediate, and particularly relates to a preparation method of (1S-(1[alpha], 2[alpha], 3[beta], 5[alpha])-2-((benzyloxy) methyl)-6-oxabicyclo [3.1. 0] hexyl-3-alcohol and an oxabicyclo compound (NT02). The invention provides a brand new preparation route and reaction process conditions, and has the advantages of high operation safety, simple method, low cost and high yield. The product yield is obviously improved, and the method is very suitable for industrial production and application.
Preparation method of oxa-dicyclohexane compound
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Paragraph 0023-0025; 0029-0031; 0035-0037, (2021/06/26)
The invention provides a preparation method of an entecavir intermediate, and particularly relates to a preparation method of an oxabicyclo [3.1.0] hexane compound (NT02). According to the preparation method, hydrogen peroxide is adopted as an oxygen source to replace tert-butyl hydroperoxide, the cost is low, the method is simple, the product yield is remarkably improved, and the preparation method is very suitable for industrial production and application.
PCSK9 INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 145; 146, (2020/07/31)
The invention relates to novel heteroaryl compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cardiovascular diseases, and methods treating sepsis or septic shock, using the novel heterocyclic compounds disclosed herein.
