19178-84-8 Usage
General Description
1-methyl-4-(9H-xanthen-9-yl)piperazine is a chemical compound that consists of a piperazine ring with a methyl group at position 1 and a xanthen-9-yl group at position 4. It is commonly used in the synthesis of fluorescent dyes and as a building block in the creation of various pharmaceutical compounds. The xanthen-9-yl group confers properties of fluorescence and has been utilized in the development of molecular probes for biological imaging and detection. The compound has also been studied for its potential as a therapeutic agent in the treatment of various medical conditions. It is important to handle this compound with caution, as it may pose risks to human health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 19178-84-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,1,7 and 8 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 19178-84:
(7*1)+(6*9)+(5*1)+(4*7)+(3*8)+(2*8)+(1*4)=138
138 % 10 = 8
So 19178-84-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H20N2O/c1-19-10-12-20(13-11-19)18-14-6-2-4-8-16(14)21-17-9-5-3-7-15(17)18/h2-9,18H,10-13H2,1H3
19178-84-8Relevant articles and documents
Steric structure–activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9
Fujiwara, Takashi,Ohira, Kasumi,Urushibara, Ko,Ito, Akihiro,Yoshida, Minoru,Kanai, Misae,Tanatani, Aya,Kagechika, Hiroyuki,Hirano, Tomoya
, p. 4318 - 4323 (2016/08/23)
Set7/9 is a histone lysine methyltransferase, but it is also thought to be involved in a wide variety of pathophysiological functions. We previously identified cyproheptadine, which has a characteristic butterfly-like molecular conformation with bent tricyclic dibenzosuberene and chair-form N-methylpiperidine moieties, as a Set7/9 inhibitor. In this work, we synthesized several derivatives in order to examine the steric structure–inhibitory activity relationship. We found that even a small change of molecular shape due to reduction or replacement of the 10,11-olefinic bond of the tricyclic ring generally resulted in a drastic decrease of the inhibitory activity. Our results should be useful not only for development of more potent and selective inhibitors, but also for the construction of novel inhibitor scaffolds.
Hypocholesteremic agents. IV. Some substituted piperazines.
Wright,Martin
, p. 390 - 391 (2007/10/08)
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