191803-52-8 Usage
General Description
(R)-CTH-JAFAPHOS is a chiral bisphosphine ligand, commonly used in asymmetric catalysis for synthesizing various organic compounds with high enantioselectivity. This chemical exhibits excellent stability and activity in the presence of air and moisture, making it a popular choice for a wide range of catalytic reactions. Its unique structure and properties enable it to effectively control the stereochemistry of the resulting products, making it a valuable tool for the pharmaceutical and fine chemical industries. Additionally, (R)-CTH-JAFAPHOS has been utilized in the development of efficient and sustainable synthetic methodologies, highlighting its versatility and potential impact on the field of organic synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 191803-52-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,8,0 and 3 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 191803-52:
(8*1)+(7*9)+(6*1)+(5*8)+(4*0)+(3*3)+(2*5)+(1*2)=138
138 % 10 = 8
So 191803-52-8 is a valid CAS Registry Number.
191803-52-8Relevant articles and documents
(-)-Sparteine-mediated stereoselective directed ortho metalation of ferrocene diamides
Laufer, Radoslaw,Veith, Ulrich,Taylor, Nicholas J.,Snieckus, Victor
, p. 356 - 369 (2007/10/03)
The utility of (-)-sparteine-mediated directed ortho metalation (DoM) has been investigated in stereoselective preparation of planar chiral ferrocenes derived from 1,1′-N,N,N′,N′- tetraisopropylferrocenedicarboxamide (5). In the synthesis of C 2-symmetric analogs of 5, the protocol (base, solvent, and two-step DoM) was found to be crucial for obtaining high enantio- and diastereo-selectivities of the products. A variety of highly enantioenriched mono and doubly functionalized derivatives of 5 have been synthesized. The synthetic applications of these compounds as chiral ligands in asymmetric alkylation of aldehydes and asymmetric palladium-catalyzed allylic substitutions have been demonstrated.