191982-10-2Relevant articles and documents
Synthesis and Evaluation of Potent and Selective c-GMP Phosphodiesterase Inhibitors
Ho, Ginny Dai,Silverman, Lisa,Bercovici, Ana,Puchalski, Chester,Tulshian, Deen,et al.
, p. 7 - 12 (2007/10/03)
Syntheses and structure-activity relationships (SAR) of cGMP selective phosphodiesterase inhibitors are discussed. Potent and selective inhibitors are produced when the C-2 position of tetracyclic guanine 1 is substituted with alkyl chains containing six carbon atoms.