Welcome to LookChem.com Sign In|Join Free

CAS

  • or

192775-97-6

192775-97-6

Post Buying Request

192775-97-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

192775-97-6 Usage

General Description

The chemical "2-[1-(4-bromophenyl)-1-methylethyl]-4,4-dimethyl-4,5-dihydrooxazoline" is a compound with a complex structure. It contains a 4-bromophenyl group, a 1-methylethyl group, and a 4,5-dihydrooxazoline ring. The compound also has two methyl groups attached to the oxazoline ring. This chemical may be used in organic synthesis or as a building block for more complex molecules. Its precise application and properties would depend on its specific chemical and physical characteristics, which can vary based on factors such as purity and synthesis method.

Check Digit Verification of cas no

The CAS Registry Mumber 192775-97-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,7,7 and 5 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 192775-97:
(8*1)+(7*9)+(6*2)+(5*7)+(4*7)+(3*5)+(2*9)+(1*7)=186
186 % 10 = 6
So 192775-97-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H18BrNO/c1-13(2)9-17-12(16-13)14(3,4)10-5-7-11(15)8-6-10/h5-8H,9H2,1-4H3

192775-97-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[2-(4-bromophenyl)propan-2-yl]-4,4-dimethyl-5H-1,3-oxazole

1.2 Other means of identification

Product number -
Other names QC-2699

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:192775-97-6 SDS

192775-97-6Synthetic route

4-bromo-α-(4,4-dimethyloxazolin-2-yl)toluene
176324-85-9

4-bromo-α-(4,4-dimethyloxazolin-2-yl)toluene

methyl iodide
74-88-4

methyl iodide

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-97-6

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

Conditions
ConditionsYield
With CH3I; potassium hexamethylsilazane; acetic acid In dichloromethane; water; isopropyl alcohol4.61 g (0.0156 mmole, 84%)
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2-Amino-2-methyl-1-propanol
124-68-5

2-Amino-2-methyl-1-propanol

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-97-6

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With thionyl chloride
Stage #2: 2-Amino-2-methyl-1-propanol With thionyl chloride
(4-bromo-phenyl)-acetic acid methyl ester
41841-16-1

(4-bromo-phenyl)-acetic acid methyl ester

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-97-6

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride
2: thionyl chloride
View Scheme
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-97-6

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

4-Chlorobutyronitrile
628-20-6

4-Chlorobutyronitrile

4-(4-chloro-1-oxobutyl)-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-98-7

4-(4-chloro-1-oxobutyl)-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

Conditions
ConditionsYield
With iodine; magnesium In tetrahydrofuran93%
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-97-6

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

tri-n-butyl(vinyl)tin
7486-35-3

tri-n-butyl(vinyl)tin

4,4-dimethyl-2-(2-(4-vinylphenyl)propan-2-yl)-4,5-dihydrooxazole
1298022-53-3

4,4-dimethyl-2-(2-(4-vinylphenyl)propan-2-yl)-4,5-dihydrooxazole

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); lithium chloride In N,N-dimethyl-formamide at 70℃; Stille coupling; Inert atmosphere;82%
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-97-6

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

4-Chlorobutanoyl chloride
4635-59-0

4-Chlorobutanoyl chloride

4-(4-chloro-1-oxobutyl)-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-98-7

4-(4-chloro-1-oxobutyl)-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran
oxirane
75-21-8

oxirane

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-97-6

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

2-(4-piperidinyl)-1H-benzimidazole
38385-95-4

2-(4-piperidinyl)-1H-benzimidazole

2-[1-(2-{4-[1-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-1-methylethyl]phenyl}ethyl)piperidin-4-yl]-1-(2-ethoxyethyl)-1H-benzimidazole

2-[1-(2-{4-[1-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-1-methylethyl]phenyl}ethyl)piperidin-4-yl]-1-(2-ethoxyethyl)-1H-benzimidazole

Conditions
ConditionsYield
Stage #1: oxirane; 4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene With n-butyllithium
Stage #2: 2-(4-piperidinyl)-1H-benzimidazole
oxirane
75-21-8

oxirane

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-97-6

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-{4-[1-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-1-methylethyl]phenyl}ethyl p-toluenesulfonate

2-{4-[1-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-1-methylethyl]phenyl}ethyl p-toluenesulfonate

Conditions
ConditionsYield
With n-butyllithium
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-97-6

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

Bilastine

Bilastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: n-butyllithium
View Scheme
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-97-6

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

2-methyl-2-[4'-(2''-hydroxyethyl)phenyl]propanoic acid

2-methyl-2-[4'-(2''-hydroxyethyl)phenyl]propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tert-butyl methyl ether; hexane / 10 h / -60 °C / Large scale
1.2: 7 h / -60 - 20 °C / Large scale
2.1: phosphoric acid / water / 30 h / 90 °C / Large scale
View Scheme
ethyleneglycol sulfate
1072-53-3

ethyleneglycol sulfate

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
192775-97-6

4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene

C16H22NO5S(1-)

C16H22NO5S(1-)

Conditions
ConditionsYield
Stage #1: 4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene With n-butyllithium In hexane; tert-butyl methyl ether at -60℃; for 10h; Large scale;
Stage #2: ethyleneglycol sulfate In hexane; tert-butyl methyl ether at -60 - 20℃; for 7h; Temperature; Solvent; Large scale;

192775-97-6Relevant articles and documents

A new and competitive synthetic approach for an antihistamine agent, bilastine

Kommera, Rajashekar,Yerrabelly, Jayaprakash Rao,Kasireddy, Venkateshwarreddy,Ghojala, Venkat Reddy,Singavarapu, Adilakshmi,Rebelli, Pradeep

, p. 815 - 821 (2018/11/06)

Efforts towards the novel synthesis of second generation non-sedating antihistamine drug, Bilastine was described in this manuscript. This competitive synthetic approach involves the convergent synthesis of Bilastine via simple Friedel-Crafts acylation as an alternate for earlier reported Stille and Suzuki couplings. The selectivity in Friedel-Crafts acylation reaction with chloro acetyl chloride on different substituted arenes was studied and employed the best conditions for the synthesis of Bilastine. Further synthetic approach involves the deoxygenation of aryl ketone to corresponding alkane in single step and finally provides Bilastine with 39% of improved overall yields, utilizing simple and cost-effective reagents, suitable for kilogram scale synthesis.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 192775-97-6