193693-69-5Relevant articles and documents
CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY
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Page/Page column 58-59, (2012/01/06)
The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.
PYRROLIDINE DERIVATIVES AS HISTAMINE RECEPTORS LIGANDS
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Page/Page column 22-23, (2010/11/08)
The present invention relates to pyrrolidine derivatives of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
Stability against enzymatic hydrolysis of endomorphin-1 analogues containing β-proline
Cardillo, Giuliana,Gentilucci, Luca,Tolomelli, Alessandra,Calienni, Maria,Qasem, Ahmed R.,Spampinato, Santi
, p. 1498 - 1502 (2007/10/03)
The enantiomer of endomorphin-1 (Tyr-Pro-Trp-PheNH2) and the analogues containing (S)-or (R)-β-proline have been synthesized, and their affinities towards μ-opioid receptors have been measured. As expected, the incubations of the different peptides with some commercially available enzymes showed that the presence of D-residues gave strong resistance towards digestion. The presence of β-proline alone is sufficient to confer good resistance against the hydrolysis of the biologically strategic Pro-Trp bond.