19437-26-4Relevant articles and documents
Structural study involving 9-(pyrid-2-yl)indolizine-1-one and related derivatives of dipyridyl methanol
Katzsch, Felix,Gruber, Tobias,Schwarzer, Anke,Weber, Edwin
, p. 215 - 222 (2019)
For the first time, the synthesis of 9-(pyrid-2-yl)indolizine-1-one from dipyridylpropargyl alcohol together with its molecular structure is reported. As the racemate was used for crystallization, the asymmetric unit contains both enantiomers. The molecular conformation of the pyridyl indolizinone scaffold of the title compound is similar to the one found for the respective chlorophenyl substituted derivative. Furthermore, we report here on the synthesis and X-ray structures of two alkylated dipyridyl methanols, which have been recovered in connection with the synthesis of the indolizinone. Both prochiral alcohols show conformational chirality in the solid state. In both compounds, intramolecular O–H … Npyridine hydrogen bonds stabilizing their molecular conformation are typical. As a common packing motif, we found a O–H?N bonding system featuring the graph set descriptor R2 2(10). With reference to the structural relationship that can be found between pharmaceutically interesting agents and title compounds, the presented molecules are promising models for future drug design.
Polarographic Behaviour of 2,2'-Dipyridyl-2-pyridylhydrazone (DPPH) and Pyridine-2-aldehyde-2-quinolylhydrazone (PAQH) at the Droping Mercury Electrode
Zuhri, Ali Z. Abu,Shalabi, Jamal S.
, p. 1335 - 1344 (1987)
The polarographic behaviour of 2,2'-dipyridyl-2-pyridylhydrazone (DPPH) and pyridine-2-aldehyde-2-quinolylhydrazone (PAQH) at dme were studied in aqueous Britton-Robinson buffers containing 50percent ethanol.The polograms consist of one irreversible wave in the acidic and alkaline medium.Two electrods are consumed in the splitting of the N-N bond.The effect of pH on the limiting current and E as well as the reduction mechanism are discussed and compared with similar compounds.The values of the kinetic parameters for the electrode reaction at different pH values are also computed from the polarographic results. - Keywords: Electrochemistry; Reduction mechanism; Kinetic parameters
Transformation Network Culminating in a Heteroleptic Cd6L6L′2Twisted Trigonal Prism
Zhang, Dawei,Ronson, Tanya K.,Xu, Lin,Xu, Lin,Nitschke, Jonathan R.
supporting information, p. 9152 - 9157 (2020/06/27)
Transformations between three-dimensional metallosupramolecular assemblies can enable switching between the different functions of these structures. Here we report a network of such transformations, based upon a subcomponent displacement strategy. The flow through this network is directed by the relative reactivities of different amines, aldehydes, and di(2-pyridyl)ketone. The network provides access to an unprecedented heteroleptic Cd6L6L′2 twisted trigonal prism. The principles underpinning this network thus allow for the design of diverse structural transformations, converting one helicate into another, a helicate into a tetrahedron, a tetrahedron into a different tetrahedron, and a tetrahedron into the new trigonal prismatic structure type. The selective conversion from one host to another also enabled the uptake of a desired guest from a mixture of guests.
Approaches for the introduction of fluorinated substituents into [1,2,3]Triazolo[1,5-a]pyridines
Chiassai, Leonardo,Adam, Rosa,Drechslerová, Marcela,Ballesteros, Rafael,Abarca, Belén
, p. 44 - 50 (2014/07/07)
[1,2,3]Triazolo[1,5-a]pyridines functionalization with a trifluoromethyl group has been achieved for the first time using different synthetic strategies. Furthermore, these scaffolds have been employed as starting material in the synthesis of new 2,6-disubstituted pyridines containing the trifluoromethyl group, compounds that are not available using other methodologies. A fluorine-mediated triazolopyridine dimerisation is described, improving the previously known synthetic method. Preliminary studies focused on exploring triazolopyridines reactivity with electrophilic fluorine have revealed a new approach for the obtainment of imidazopyridines.
