194804-72-3

• 

• Basic information

  1. Product Name: GARENOXACIN
  2. Synonyms: 1-Cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
  3. CAS NO:194804-72-3
  4. Molecular Formula: C23H22N2O4
  5. Molecular Weight: 390.437
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 194804-72-3.mol
  9. Article Data: 3

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: GARENOXACIN(CAS DataBase Reference)
  10. NIST Chemistry Reference: GARENOXACIN(194804-72-3)
  11. EPA Substance Registry System: GARENOXACIN(194804-72-3)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 194804-72-3(Hazardous Substances Data)

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  Cas No: 194804-72-3

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194804-72-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 194804-72-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,8,0 and 4 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 194804-72:
(8*1)+(7*9)+(6*4)+(5*8)+(4*0)+(3*4)+(2*7)+(1*2)=163
163 % 10 = 3
So 194804-72-3 is a valid CAS Registry Number.

194804-72-3Upstream product

• 194804-45-0 ethyl (+)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2-trityliso-indolin-5-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 194804-41-6 Ethyl (+)-1-cyclopropyl-8-difluoromethoxy-7-[2-benzyloxycarbonyl-1-methylisoindolin-5-yl]-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 194805-07-7 ethyl 7-bromo-1-cyclopropyl-8-difluoromethoxy-4-oxo-1,4-dihydro-3-quinoline-carboxylate 
• 194805-12-4 2-benzyloxycarbonyl-5-bromo-1-methylisoindoline 
• 194804-56-3 (+)-1-Cyclopropyl-8-difluoromethoxy-7-[2-benzyloxycarbonyl-1-methylisoindolin-5-yl]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 223595-20-8 2-[(1R)-1-methyl-2-trityl-2,3-dihydro-1H-5-isoindolyl]-1,3,6,2-dioxazaborocane 
• 194805-14-6 (+)-(R)-5-bromo-1-methyl-2-(triphenylmethyl)isoindoline 

194804-72-3Downstream Products

194804-72-3Relevant articles and documents

Preparation method for garenoxacin and intermediate thereof

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Paragraph 0043; 0044; 0045; 0046; 0047; 0048, (2017/07/20)

The invention provides a preparation method for garenoxacin and an intermediate thereof. The preparation method comprises the following steps: with a compound 5 as a raw material, reacting the compound 5 with bis(pinacolato)diboron or triisopropyl borate so as to obtain a compound 4; separately adding 7-bromo-1-cyclopropyl-8-difluoromethoxy-1,4-dihydro-4-oxoquinoline-3-ethyl carboxylate, a palladium catalyst and inorganic aqueous alkali and carrying out a reaction so as to obtain a compound 3; and subjecting the compound 3 to hydrolysis and a reduction reaction so as to obtain a compound 2 and garenoxacin (a compound 1). The compound 3 has excellent stability; raw materials for preparation of garenoxacin are cheap and easily available; reaction operation is simple; yield is high; litter waste gas, waste water and industrial residue are produced; and thus, the preparation method has good industrial prospects.

Quinolonecarboxylic acid derivatives or salts thereof

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, (2008/06/13)

PCT No. PCT/JP97/00317 Sec. 371 Date Aug. 10, 1998 Sec. 102(e) Date Aug. 10, 1998 PCT Filed Feb. 7, 1997 PCT Pub. No. WO97/29102 PCT Pub. Date Aug. 14, 1997The present invention relates to a quinolone-carboxylic acid derivative represented by the general

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