195060-95-8Relevant articles and documents
Palladium-catalyzed amidocarbonylation - A new, efficient synthesis of N-acyl amino acids
Beller,Eckert,Vollmuller,Bogdanovic,Geissler
, p. 1494 - 1496 (2007/10/03)
For the first time palladium catalysts have been used successfully for the amidocarbonylation reaction. The activity of the cobalt catalysts that were used exclusively beforehand has now been exceeded by an order of magnitude, and the reaction can be performed under far milder conditions. Palladium-catalyzed amidocarbonylation reactions can now be used for the synthesis of a much wider range of N-acyl amino acids.
Composition containing a penem or carbapenem antibiotic
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, (2008/06/13)
Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. The composition may be prepared by simple mixing.
