19585-93-4Relevant articles and documents
13C and 1H NMR Studies of Structure and Tautomerism in Some Perimidines
Woodgate, P. D.,Herbert, J. M.,Denny, W. A.
, p. 191 - 196 (1988)
The 13C NMR spectra of some 1- and 2-substituted perimidines and perimidinium salts are discussed and assigned.Although the spectra of most of the 2-substituted perimidines are comparatively simple, several examples display 13C and 1H spectral characteristics indicative of inhibition of prototropic tautomerism.KEY WORDS 13C NMR Perimidines Perimidinium salts 1H NMR Tautomerism
Potential Antitumor Agents. 53. Synthesis, DNA Binding Properties, and Biological Activity of Perimidines Designed as "Minimal" DNA-Intercalating Agents
Herbert, John M.,Woodgate, Paul D.,Denny, William A.
, p. 2081 - 2086 (1987)
A series of compounds based on perimidine have been synthesized and evaluated for their DNA-binding properties and antitumor activity.The fused tricyclic perimidine chromophore appears to be the minimal structural requirement for intercalative binding to DNA since the mode of binding could be dictated by the position of attachment of the side chain.The intercalating compounds have DNA association constants (log K = 5.8-6.5) and cytotoxic potencies (IC50 = 500-1500 nM) comparable to those shown by other classes of linear, tricyclic DNA-intercalating antitumor agents (acridinecarboxamides, phenazinecarboxamides), but none of the compounds showed in vivo activity.
HETEROCYCLIC ANALOGS OF PLEIADIENE. LVI. A NEW REACTION OF PERIMIDINES AND BENZIMIDAZOLES - DIMERIZATION UNDER THE INFLUENCE OF DILITHIOBENZOPHENONE WITH SUBSEQUENT AROMATIZATION OF ONE HETEROCYCLE AND OPENING OF THE OTHER
Pozharskii, A. F.,Smirnova, L. P.,Klyuev, N. A.,Starshikov, N. M.
, p. 1427 - 1434 (2007/10/02)
Under the influence of dilithiobenzophenone in THF 1-substituted perimidines and benzimidazoles undergo dimerization at position 2.The initially formed dilithio derivative of the bisdihydro compound then undergoes a complex transformation of the hydride disproportionation type, as a result of which one of the heterocycles on the dimer is aromatized while the other is opened.
