196597-79-2Relevant articles and documents
Preparation method of ramelteon
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Paragraph 0016-0022, (2020/06/16)
The invention belongs to the field of medicinal chemistry, and mainly relates to a (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)-1-ethylamine compound represented by a formula I. The method has the advantages that the operation is simple, the steps are reduced compared with the previous method, the route is shortened, and the used solvent is single in variety, convenient to recycle and high in yield, wherein the formula I is defined in the specification.
PROCESS FOR THE PREPARATION OF AN INTERMEDIATE FOR RAMELTEON
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Page/Page column 10, (2011/04/14)
The present invention relates to a process for the preparation of (2E)- 1,2,6,7- tetrahydro-8H-indeno[5,4-b]furan-8-ylideneethanenitrile of Formula (I). The present invention further relates to a process for the preparation of ramelteon using (2E)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylideneethanenitrile of Formula (I) as an intermediate.
SYNTHESIS OF (S)-N-[2-(1,6,7,8-TETRAHYDRO-2H-INDENO-[5,4-B]FURAN-8-YL)ETHYL]PROPIONAMIDE
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Page/Page column 22-23, (2010/09/03)
The present invention relates in general to the field of organic chemistry and in particular to the preparation of (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide, i.e. ramelteon, and analogues thereof.