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199480-42-7

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199480-42-7 Usage

Uses

3,4-Dihydroisoquinoline-2(1H)-carbonyl Chloride is used in preparation of the multi-targeted Carbamate compounds and their medical application.

Check Digit Verification of cas no

The CAS Registry Mumber 199480-42-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,4,8 and 0 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 199480-42:
(8*1)+(7*9)+(6*9)+(5*4)+(4*8)+(3*0)+(2*4)+(1*2)=187
187 % 10 = 7
So 199480-42-7 is a valid CAS Registry Number.

199480-42-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,4-dihydro-1H-isoquinoline-2-carbonyl chloride

1.2 Other means of identification

Product number -
Other names 1,2,3,4-tetrahydroisoquinoline-2-carbonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:199480-42-7 SDS

199480-42-7Relevant articles and documents

Debenzylation of tertiary amines using phosgene or triphosgene: An efficient and rapid procedure for the preparation of carbamoyl chlorides and unsymmetrical ureas. Application in carbon-11 chemistry

Lemoucheux, Laurent,Rouden, Jacques,Ibazizene, Me?ziane,Sobrio, Franck,Lasne, Marie-Claire

, p. 7289 - 7297 (2007/10/03)

Efficient and rapid preparations of carbamoyl chlorides and unsymmetrical ureas from tertiary amines and phosgene or its safe equivalent triphosgene [bis(trichloromethyl)carbonate, BTC] are described. First, the reaction of stoichiometric amounts of phosgene with secondary amines was revisited, and it was shown that the formation of carbamoyl chlorides in high yields required careful adjustments of experimental conditions and the use of pyridine as an HCl scavenger. A phosgene-mediated dealkylation of triethylamine was observed when this base was used instead of pyridine. Taking advantage of this observation, a strategy of synthesis of carbamoyl chlorides from tertiary amines and phosgene has been developed. N-Alkyl-N-benzyl(substituted)tetrahydroisoquinolines, -piperazines, -piperidines, or -anilines were treated with stoichiometric amounts of phosgene (or BTC) in CH2Cl2. Tertiary amines bearing electron-enriched benzyl group(s) afforded carbamoyl chlorides in excellent yields and without any contamination by symmetrical ureas. Subsequent additions of primary or secondary amines to these carbamoyl chlorides produced unsymmetrical ureas in single-pot and high-yielding operations. This methodology was applied in 11C-chemistry. From [ 11C]phosgene, a common precursor used in the preparation of radiotracers for positron emission tomography, a rapid and efficient synthesis of 11C-carbamoyl chlorides and 11C-unsymmetrical ureas derived from tetrahydroisoquinoline and piperazine is described. The first example of 11C-amide formation from the reaction of a 11C-carbamoyl chloride and an organometallic (cyanocuprate or a Grignard reagent in the presence of a nickel catalyst) is also presented.

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