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19952-47-7

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19952-47-7 Usage

Chemical Properties

white to light beige or greyish crystalline powder

Uses

2-Amino-4-chlorobenzothiazole is a benzothiazole derivative that shows in vivo antiviral effects against various influenza A2 strains.

General Description

Cream colored crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 2-AMINO-4-CHLOROBENZOTHIAZOLE emits very toxic fumes of chloride ion, SOx and NOx.

Fire Hazard

Flash point data for 2-AMINO-4-CHLOROBENZOTHIAZOLE are not available; however, 2-AMINO-4-CHLOROBENZOTHIAZOLE is probably combustible.

Check Digit Verification of cas no

The CAS Registry Mumber 19952-47-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,9,5 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 19952-47:
(7*1)+(6*9)+(5*9)+(4*5)+(3*2)+(2*4)+(1*7)=147
147 % 10 = 7
So 19952-47-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H5ClN2S/c8-4-2-1-3-5-6(4)10-7(9)11-5/h1-3H,(H2,9,10)

19952-47-7 Well-known Company Product Price

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  • Detail
  • Alfa Aesar

  • (A18160)  2-Amino-4-chlorobenzothiazole, 97%   

  • 19952-47-7

  • 5g

  • 645.0CNY

  • Detail
  • Alfa Aesar

  • (A18160)  2-Amino-4-chlorobenzothiazole, 97%   

  • 19952-47-7

  • 25g

  • 2069.0CNY

  • Detail
  • Alfa Aesar

  • (A18160)  2-Amino-4-chlorobenzothiazole, 97%   

  • 19952-47-7

  • 100g

  • 5603.0CNY

  • Detail
  • Aldrich

  • (133434)  2-Amino-4-chlorobenzothiazole  97%

  • 19952-47-7

  • 133434-5G

  • 694.98CNY

  • Detail
  • Aldrich

  • (133434)  2-Amino-4-chlorobenzothiazole  97%

  • 19952-47-7

  • 133434-25G

  • 2,235.87CNY

  • Detail

19952-47-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-chloro-1,3-benzothiazol-2-amine

1.2 Other means of identification

Product number -
Other names 4-chlorobenzo[d]thiazol-2-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19952-47-7 SDS

19952-47-7Relevant articles and documents

Iodine-catalyzed amination of benzothiazoles with KSeCN in water to access primary 2-aminobenzothiazoles

Chen, Xiran,Fu, Lianrong,Hao, Xin-Qi,Shi, Linlin,Song, Mao-Ping,Zhu, Xinju,Zhu, Yu-Shen

supporting information, (2021/09/09)

A facile and sustainable approach for the amination of benzothiazoles with KSeCN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to afford various primary 2-amino benzothiazoles in up to 96% yield. A series of control experiments were performed, suggesting a ring-opening mechanism was involved via a radical process. This protocol provides efficient synthesis of primary 2-aminobenzothiazoles

SN-Donor methylthioanilines and copper(II) complexes: Synthesis, spectral properties, and in vitro antimicrobial activity

Olalekan, Temitope E.,Ogunlaja, Adeniyi S.,Watkins, Gareth M.

, (2019/04/25)

Methylthioanilines, a series of sulfur-nitrogen donor ligands substituted with OCH3, CH3, Cl, and Br, and their copper(II) complexes have been synthesized and characterized by 1H and 13C NMR, elemental analysis, FTIR, UV-Vis and EPR spectra, molar conductance, and magnetic susceptibility measurements. The NMR spectra of the ligands revealed that the para/ortho protons and para carbon were sensitive to the electronic effect of substituents. The CHNS analysis presented CuLCl2 (L = OCH3, CH3, Cl) and CuL2Cl2 (L = Br) stoichiometries for the copper complexes. FTIR spectra showed that the bidentate ligands were coordinated to the copper ion through their nitrogen and sulfur atoms. The electronic spectra have suggested square planar and octahedral geometries for these complexes. The EPR spectra demonstrated that the solid state copper(II) complexes possess dx2-y2 orbital ground state and g= > g > 2.0023 in a tetragonal environment. The compounds were evaluated for in vitro antimicrobial activity against S. aureus, B. subtilis, E. coli, and C. albicans. The copper complexes showed higher activity than the parent ligands against S. aureus and B. subtilis; the electron-donating OCH3 and CH3 derivatives were more active than the withdrawing Br- A nd Cl-substituted compounds.

Compounds for treating spinal muscular atrophy

-

Page/Page column 321; 322, (2017/05/02)

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

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